PMID- 15212666
OWN - NLM
STAT- MEDLINE
DCOM- 20040727
LR  - 20051117
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 51
IP  - 5
DP  - 2004 May
TI  - Vasoconstrictively acting AT1R A1166C and NOS3 4/5 polymorphisms in recurrent 
      spontaneous abortions (RSA).
PG  - 323-8
AB  - PROBLEM: Inadequate uteroplacental perfusion is one of the main reasons for 
      recurrent spontaneous abortions (RSA). Coagulation, fibrinolysis, and 
      vasoconstriction affect tissue perfusion. These systems are regulated by 
      different gene products. Polymorphisms can modulate the expression levels of the 
      respective genes and can thereby affect perfusion. Vasoconstriction is influenced 
      by the expression of endothelial nitric oxide synthase (eNOS) and of the 
      angiotensinogen II type 1 receptor (AT1R). METHOD: The aim of our study was to 
      investigate, whether two polymorphisms in the AT1R and NOS3 genes shown to result 
      in maternal vasoconstriction are associated with an increased risk for RSA. 
      RESULTS: Our data indicate that the vasoconstrictively acting genotypes AT1R C/C 
      and NOS3 4/4 are of similar prevalence in RSA patients and in controls. 
      CONCLUSION: Results do not show any influence of the polymorphisms studied on 
      early pregnancy development. This is in concordance with the concept of an 
      independent regulation of placental perfusion.
FAU - Buchholz, Tina
AU  - Buchholz T
AD  - Department of Obstetrics and Gynecology - Grosshadern, Klinikum der Universitat 
      Munchen, Germany.
FAU - Lohse, Peter
AU  - Lohse P
FAU - Kosian, Elke
AU  - Kosian E
FAU - Thaler, Christian J
AU  - Thaler CJ
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Receptor, Angiotensin, Type 2)
RN  - 9007-49-2 (DNA)
RN  - EC 1.14.13.39 (NOS3 protein, human)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
SB  - IM
MH  - Abortion, Habitual/*genetics/physiopathology
MH  - Adult
MH  - Case-Control Studies
MH  - DNA/genetics/isolation & purification
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Leukocytes/metabolism
MH  - Middle Aged
MH  - Nitric Oxide Synthase/*genetics
MH  - Nitric Oxide Synthase Type III
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Pregnancy
MH  - Receptor, Angiotensin, Type 2/*genetics
MH  - Tandem Repeat Sequences/genetics
MH  - Vasoconstriction/genetics/physiology
EDAT- 2004/06/24 05:00
MHDA- 2004/07/28 05:00
CRDT- 2004/06/24 05:00
PHST- 2004/06/24 05:00 [pubmed]
PHST- 2004/07/28 05:00 [medline]
PHST- 2004/06/24 05:00 [entrez]
AID - AJI163 [pii]
AID - 10.1111/j.1600-0897.2004.00163.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2004 May;51(5):323-8. doi: 10.1111/j.1600-0897.2004.00163.x.