PMID- 1521319
OWN - NLM
STAT- MEDLINE
DCOM- 19921015
LR  - 20190827
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 68
IP  - 1
DP  - 1992 Jul 24
TI  - Postnatal administration of dihydrotestosterone to the male rat abolishes sexual 
      dimorphism in the accessory olfactory bulb: a volumetric study.
PG  - 132-5
AB  - The regulatory action of the non-aromatizable androgen dihydrotestosterone (DHT) 
      on sexual differentiation of the volume of the rat accessory olfactory bulb (AOB) 
      was studied. Postnatal treatment with DHT (180 micrograms/day) carried out daily 
      between days 6 and 20 produced a drastic reduction in overall AOB size and that 
      of its constituent neural layers in genetic males with respect to intact and 
      control males. The volumetric measures found in DHT-treated males did not differ 
      from those shown by the intact females. These results, which indicate a 
      demasculinization and a feminization of the AOB volume in gonadally intact male 
      rats induced by DHT, are discussed in relation to the presumably regulatory role 
      of DHT on neuron populations during the sexual organizational process of the 
      brain.
FAU - Valencia, A
AU  - Valencia A
AD  - Departamento de Psicobiologia, Universidad Nacional de Educacion a Distancia, 
      Ciudad Universitaria, Madrid, Spain.
FAU - Collado, P
AU  - Collado P
FAU - Cales, J M
AU  - Cales JM
FAU - Segovia, S
AU  - Segovia S
FAU - Perez Laso, C
AU  - Perez Laso C
FAU - Rodriguez Zafra, M
AU  - Rodriguez Zafra M
FAU - Guillamon, A
AU  - Guillamon A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 08J2K08A3Y (Dihydrotestosterone)
SB  - IM
MH  - Animals
MH  - Dihydrotestosterone/*pharmacology
MH  - Female
MH  - Male
MH  - Olfactory Bulb/*drug effects/growth & development
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Sex Characteristics
MH  - Sex Differentiation/drug effects
EDAT- 1992/07/24 00:00
MHDA- 1992/07/24 00:01
CRDT- 1992/07/24 00:00
PHST- 1992/07/24 00:00 [pubmed]
PHST- 1992/07/24 00:01 [medline]
PHST- 1992/07/24 00:00 [entrez]
AID - 0165-3806(92)90255-U [pii]
AID - 10.1016/0165-3806(92)90255-u [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 1992 Jul 24;68(1):132-5. doi: 
      10.1016/0165-3806(92)90255-u.