PMID- 15214849
OWN - NLM
STAT- MEDLINE
DCOM- 20040826
LR  - 20131121
IS  - 0931-184X (Print)
IS  - 0931-184X (Linking)
VI  - 51
IP  - 3
DP  - 2004 Apr
TI  - Effect of Escherichia coli heat-labile enterotoxin on the myoelectric activity of 
      the duodenum in weaned pigs.
PG  - 106-12
AB  - The objective of the present study was to elucidate the effect of subclinical 
      doses of Escherichia coli heat-labile enterotoxin (LT) on the antro-duodenal 
      myoelectric activities of weaned pigs. Twelve weaned pigs were surgically 
      implanted with three pairs of electrodes on the antrum 3 cm before the pylorus, 5 
      and 20 cm after the pylorus on the duodenum, respectively. An infusion cannula 
      was inserted into the duodenum between duodenal electrodes. Using a wireless 
      telemetry recording system, an electromyography (EMG) tracing lasting at least 24 
      h was recorded as the control, then another 24-h EMG recording was performed with 
      a bolus intraduodenal infusion of LT (0.1 and 0.5 microg/kg b.w.). After a 1- to 
      2-day break, a 5-fold higher dose of LT was administered using the same protocol. 
      In the antrum, LT administration barely modified the EMG signal. However, in the 
      duodenum it prolonged the duration of phase II and the migrating myoelectric 
      complex (MMC) cycle when compared with the control. The number of duodenal MMC 
      cycles was also significantly diminished. Moreover, the migrating velocity of 
      phase III was increased. The migrating action potential complex (MAPC) was 
      present both without and with LT, but occurred more frequently following LT 
      administration. In conclusion, LT caused a dose-dependent, lagged alteration in 
      the duodenal MMC in weaned pigs, involving a reduction of the MMC number by 
      lengthening phase II, increased phase III migration velocity, and increased MAPC 
      frequency. The disturbances did not, however, result in diarrhoea and may reflect 
      the induction of a local protection mechanism of the gut to expel unwanted 
      foreign content from the lumen of the upper gut.
FAU - Yao, G
AU  - Yao G
AD  - The Kielanowski Institute of Animal Physiology and Nutrition, Jablonna, Poland.
FAU - Wolinski, J
AU  - Wolinski J
FAU - Zabielski, R
AU  - Zabielski R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - J Vet Med A Physiol Pathol Clin Med
JT  - Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
JID - 100955112
RN  - 0 (Bacterial Toxins)
RN  - 0 (Endotoxins)
RN  - 0 (Enterotoxins)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (heat stable toxin (E coli))
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Bacterial Toxins/*toxicity
MH  - Diarrhea/physiopathology/*veterinary
MH  - Duodenum/*drug effects
MH  - Endotoxins/*toxicity
MH  - Enterotoxins/*toxicity
MH  - Escherichia coli/*metabolism
MH  - Escherichia coli Infections/physiopathology/veterinary
MH  - Escherichia coli Proteins
MH  - Male
MH  - Myoelectric Complex, Migrating/drug effects
MH  - Swine
MH  - Swine Diseases/*physiopathology
EDAT- 2004/06/25 05:00
MHDA- 2004/08/27 05:00
CRDT- 2004/06/25 05:00
PHST- 2004/06/25 05:00 [pubmed]
PHST- 2004/08/27 05:00 [medline]
PHST- 2004/06/25 05:00 [entrez]
AID - JVA610 [pii]
AID - 10.1111/j.1439-0442.2004.00610.x [doi]
PST - ppublish
SO  - J Vet Med A Physiol Pathol Clin Med. 2004 Apr;51(3):106-12. doi: 
      10.1111/j.1439-0442.2004.00610.x.