PMID- 15215890
OWN - NLM
STAT- MEDLINE
DCOM- 20050210
LR  - 20061115
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 5
IP  - 6
DP  - 2004 Sep
TI  - Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients 
      with ulcerative colitis.
PG  - 477-83
AB  - Ulcerative colitis (UC) is a multifactorial disorder with both genetic and 
      environmental factors. HLA-B*52 and DRB1*1502 are reported to be strongly 
      associated with UC in Japan. However, the actual susceptible gene has not been 
      identified yet. In this study, to map precisely the susceptible locus for UC, we 
      performed association mapping in the chromosome 6p using 24 microsatellite 
      markers distributed over 16 Mb. A total of 183 patients with UC and 186 healthy 
      controls (HC) were included in this study. In all, 15 markers around the human 
      leukocyte antigen (HLA) region showed statistical significance in the genotypic 
      differentiation test concerned with the allelic distribution between the UC and 
      HC. Especially, the markers between the centromeric region of HLA class I and the 
      telomeric region of class III showed remarkably low P-values and the allele239 of 
      C2-4-4 in class I marker showed the strongest association (Pc=2.9 x 10(-9): 
      OR=3.74, 95% CI=2.50-5.60). Furthermore, we found strong linkage disequilibrium 
      (LD) between the allele239 of C2-4-4 and HLA-B*52 in haplotype analysis. These 
      results provide evidence that, in Japanese, important determinants of disease 
      susceptibility to UC may exist in HLA, especially between the centromeric region 
      of class I and the telomeric region of class III, under the strong LD with 
      HLA-B*52.
FAU - Nomura, E
AU  - Nomura E
AD  - Division of Gastroenterology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan. enomura@int3.med.tohoku.ac.jp
FAU - Kinouchi, Y
AU  - Kinouchi Y
FAU - Negoro, K
AU  - Negoro K
FAU - Kojima, Y
AU  - Kojima Y
FAU - Oomori, S
AU  - Oomori S
FAU - Sugimura, M
AU  - Sugimura M
FAU - Hiroki, M
AU  - Hiroki M
FAU - Takagi, S
AU  - Takagi S
FAU - Aihara, H
AU  - Aihara H
FAU - Takahashi, S
AU  - Takahashi S
FAU - Hiwatashi, N
AU  - Hiwatashi N
FAU - Shimosegawa, T
AU  - Shimosegawa T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - *Chromosome Mapping
MH  - Chromosomes, Human, Pair 6/*genetics
MH  - Colitis, Ulcerative/*genetics
MH  - Disease Susceptibility
MH  - Female
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Japan
MH  - Linkage Disequilibrium
MH  - Major Histocompatibility Complex/*genetics
MH  - Male
MH  - Microsatellite Repeats/genetics
MH  - Telomere/genetics
EDAT- 2004/06/25 05:00
MHDA- 2005/02/11 09:00
CRDT- 2004/06/25 05:00
PHST- 2004/06/25 05:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2004/06/25 05:00 [entrez]
AID - 6364114 [pii]
AID - 10.1038/sj.gene.6364114 [doi]
PST - ppublish
SO  - Genes Immun. 2004 Sep;5(6):477-83. doi: 10.1038/sj.gene.6364114.