PMID- 15216457
OWN - NLM
STAT- MEDLINE
DCOM- 20040813
LR  - 20101118
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 190
IP  - 2
DP  - 2004 Jul 15
TI  - Chemokine receptor expression on mucosal dendritic cells from the endocervix of 
      healthy women.
PG  - 246-50
AB  - Dendritic cells (DCs) may be an initial target of human immunodeficiency virus 
      (HIV) during heterosexual transmission. An analysis of DCs in the intraepithelial 
      layer of the endocervix of the female genital tract from healthy women showed 
      that ~20% expressed CD1a, and 30% expressed cutaneous leukocyte antigen (CLA). 
      Langerin, a molecule associated with Langerhans DCs, was on CD1a-positive and 
      -negative DCs and on CLA-positive cells. CCR5 and CXCR4 were detected on 
      CD1a-positive and -negative cervical DCs. These findings suggest that DCs in the 
      genital tract are potential targets for macrophage-tropic and lymphotropic 
      strains of HIV.
FAU - Prakash, Manyu
AU  - Prakash M
AD  - Department of Immunology, Faculty of Medicine, Chelsea and Westminster Hospital, 
      London, United Kingdom.
FAU - Kapembwa, Moses S
AU  - Kapembwa MS
FAU - Gotch, Frances
AU  - Gotch F
FAU - Patterson, Steve
AU  - Patterson S
LA  - eng
PT  - Journal Article
DEP - 20040618
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Antigens, Surface)
RN  - 0 (CD1a antigen)
RN  - 0 (CD207 protein, human)
RN  - 0 (CTAGE1 protein, human)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, CXCR4)
RN  - 0 (Receptors, Chemokine)
SB  - IM
MH  - Antigens, CD
MH  - Antigens, CD1/analysis
MH  - Antigens, Differentiation, T-Lymphocyte
MH  - Antigens, Neoplasm
MH  - Antigens, Surface/analysis
MH  - Cervix Uteri/chemistry/*cytology
MH  - Dendritic Cells/*chemistry
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Lectins, C-Type/analysis
MH  - Mannose-Binding Lectins/analysis
MH  - Membrane Glycoproteins/analysis
MH  - Mucous Membrane/chemistry/cytology
MH  - Receptors, CCR5/analysis
MH  - Receptors, CXCR4/analysis
MH  - Receptors, Chemokine/*analysis
EDAT- 2004/06/25 05:00
MHDA- 2004/08/17 10:00
CRDT- 2004/06/25 05:00
PHST- 2003/06/09 00:00 [received]
PHST- 2004/02/02 00:00 [accepted]
PHST- 2004/06/25 05:00 [pubmed]
PHST- 2004/08/17 10:00 [medline]
PHST- 2004/06/25 05:00 [entrez]
AID - JID31257 [pii]
AID - 10.1086/422034 [doi]
PST - ppublish
SO  - J Infect Dis. 2004 Jul 15;190(2):246-50. doi: 10.1086/422034. Epub 2004 Jun 18.