PMID- 15217397
OWN - NLM
STAT- MEDLINE
DCOM- 20040818
LR  - 20141120
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 19
IP  - 12
DP  - 2004 Jun
TI  - Selective antagonism of medial prefrontal cortex D4 receptors decreases 
      fear-related behaviour in rats.
PG  - 3393-7
AB  - It is well known that the mesolimbocortical dopamine pathway is highly active 
      during periods of stress and fear. However, very little research has directly 
      examined how dopamine receptors in this pathway influence fear-related behaviour. 
      The present study examined the effects of selective antagonism of D(4), D(1) and 
      D(2) dopamine receptors of the medial prefrontal cortex (MPFC) on rats' fear 
      behaviour in the elevated plus-maze and the shock-probe burying tests. The 
      results demonstrated that bilateral intra-MPFC infusions of the highly selective 
      D(4) antagonist, L-745 870 (0.2, 1 or 10 nmol/0.5 microL), increased the 
      percentage of open-arm entries and open-arm time in the elevated plus-maze test 
      (1 nmol/0.5 microL), and decreased the duration of burying in the shock-probe 
      test (0.2 or 1 nmol/0.5 microL). Furthermore, none of the doses of the D(4) 
      antagonist affected measures of general activity or pain sensitivity. Intra-MPFC 
      infusions of the D(1) antagonist, SCH-23390 (0.2 or 1 nmol/0.5 microL), or the 
      D(2) antagonist, remoxipride (0.2, 1 or 10 nmol/0.5 microL), had no significant 
      behavioural effects in either test. Taken together, these findings suggest that 
      MPFC D(4) receptors may play an important role in the mediation of fear-related 
      behaviour.
FAU - Shah, Akeel A
AU  - Shah AA
AD  - Department of Psychology, University of Alberta, Edmonton, AB, Canada. 
      aashah@ualberta.ca
FAU - Sjovold, Travis
AU  - Sjovold T
FAU - Treit, Dallas
AU  - Treit D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Dopamine D2 Receptor Antagonists)
RN  - 0 (Drd4 protein, rat)
RN  - 137750-34-6 (Receptors, Dopamine D4)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects/*physiology
MH  - Dopamine Antagonists/administration & dosage
MH  - *Dopamine D2 Receptor Antagonists
MH  - Electroshock
MH  - Fear/drug effects/*physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Maze Learning/drug effects/physiology
MH  - Pain Threshold/drug effects
MH  - Prefrontal Cortex/drug effects/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D4
EDAT- 2004/06/26 05:00
MHDA- 2004/08/19 05:00
CRDT- 2004/06/26 05:00
PHST- 2004/06/26 05:00 [pubmed]
PHST- 2004/08/19 05:00 [medline]
PHST- 2004/06/26 05:00 [entrez]
AID - EJN3447 [pii]
AID - 10.1111/j.0953-816X.2004.03447.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2004 Jun;19(12):3393-7. doi: 10.1111/j.0953-816X.2004.03447.x.