PMID- 15219229
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20050725
LR  - 20181113
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 3
DP  - 2004 Jun 25
TI  - Increased fluidity and oxidation of malarial lipoproteins: relation with severity 
      and induction of endothelial expression of adhesion molecules.
PG  - 15
AB  - INTRODUCTION: Oxidative stress has been demonstrated in malaria. The potential 
      oxidative modification of lipoproteins derived from malaria patients was studied. 
      These oxidized lipids may have role in pathogenesis of malaria. METHOD: The 
      plasma lipid profile and existence of oxidized forms of very low density 
      lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein 
      (HDL) were investigated in malaria (17 mild and 24 severe patients) and 37 
      control subjects. Thiobarbituric acid reactive substances (TBARs), conjugated 
      dienes, tryptophan fluorescence and fluidity of lipoproteins were determined as 
      markers of oxidation. The biological effect of malarial lipoproteins was assessed 
      by the expression of adhesion molecules on endothelial cells. RESULTS: Malarial 
      lipoproteins had decreased cholesterol (except in VLDL) and phospholipid. The 
      triglyceride levels were unchanged. The cholesterol/phospholipid ratio of LDL was 
      decreased in malaria, but increased in VLDL and HDL. TBARs and conjugate dienes 
      were increased in malarial lipoproteins, while the tryptophan fluorescence was 
      decreased. The fluidity of lipoproteins was increased in malaria. These indicated 
      the presence of oxidized lipoproteins in malaria by which the degree of oxidation 
      was correlated with severity. Of three lipoproteins from malarial patients, LDL 
      displayed the most pronounced oxidative modification. In addition, oxidized LDL 
      from malaria patients increased endothelial expression of adhesion molecules. 
      CONCLUSION: In malaria, the lipoproteins are oxidatively modified, and the degree 
      of oxidation is related with severity. Oxidized LDL from malarial patients 
      increases the endothelial expression of adhesion molecules. These suggest the 
      role of oxidized lipoproteins, especially LDL, on the pathogenesis of disease.
FAU - Sibmooh, Nathawut
AU  - Sibmooh N
AD  - Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, 
      Thailand. scnsm@mahidol.ac.th
FAU - Yamanont, Paveena
AU  - Yamanont P
FAU - Krudsood, Srivicha
AU  - Krudsood S
FAU - Leowattana, Wattana
AU  - Leowattana W
FAU - Brittenham, Gary
AU  - Brittenham G
FAU - Looareesuwan, Sornchai
AU  - Looareesuwan S
FAU - Udomsangpetch, Rachanee
AU  - Udomsangpetch R
LA  - eng
GR  - D43 TW006240/TW/FIC NIH HHS/United States
PT  - Journal Article
DEP - 20040625
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
PMC - PMC449728
EDAT- 2004/06/29 05:00
MHDA- 2004/06/29 05:01
PMCR- 2004/06/25
CRDT- 2004/06/29 05:00
PHST- 2004/05/20 00:00 [received]
PHST- 2004/06/25 00:00 [accepted]
PHST- 2004/06/29 05:00 [pubmed]
PHST- 2004/06/29 05:01 [medline]
PHST- 2004/06/29 05:00 [entrez]
PHST- 2004/06/25 00:00 [pmc-release]
AID - 1476-511X-3-15 [pii]
AID - 10.1186/1476-511X-3-15 [doi]
PST - epublish
SO  - Lipids Health Dis. 2004 Jun 25;3:15. doi: 10.1186/1476-511X-3-15.