PMID- 15219378
OWN - NLM
STAT- MEDLINE
DCOM- 20050210
LR  - 20151119
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 6
DP  - 2004 Jun
TI  - HLA-G genotype is associated with fetoplacental growth.
PG  - 586-93
AB  - The human leukocyte antigen (HLA)-G is expressed by extravillous cytotrophoblast 
      cells in the feto-maternal contact zone. Polymorphisms have been described in the 
      HLA-G gene and have been linked with differences in HLA-G mRNA alternative 
      splicing patterns and protein expression. Differences in the isoform profile or 
      the degree of HLA-G expression may influence cytokine production and, thereby, 
      placental and fetal growth. Associations between a 14 bp deletion polymorphism in 
      the 3'UTR part of the HLA-G gene and birth weight in relation to gestational age 
      and placental weight were studied in 47 pregnancies complicated with preeclampsia 
      and 87 with no preeclampsia. An HLA-G genotype homozygous for the presence of the 
      14 bp sequence polymorphism was significantly associated with increased birth 
      weight in relation to gestational age (one-way analysis of variance; 2 degrees of 
      freedom: p = 0.02) and with placental weight at birth (>38 weeks of gestation; 
      +14 bp/+14 bp vs others; unpaired t-test: p = 0.03). There was also a slightly 
      higher placental ratio in the offspring with the +14 bp/+14 bp genotype. The 
      implications of these findings are discussed in relation to certain complications 
      of pregnancy and in an evolutionary perspective.
FAU - Hviid, Thomas Vauvert
AU  - Hviid TV
AD  - Department of Clinical Biochemistry, Copenhagen University Hospital, 
      Rigshospitalet, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark. hviid@dadlnet.dk
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Alternative Splicing/genetics/immunology
MH  - Birth Weight/genetics/*immunology
MH  - Female
MH  - Fetus/embryology/*immunology
MH  - Gestational Age
MH  - HLA Antigens/genetics/*immunology
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/genetics/*immunology
MH  - Humans
MH  - Placenta/*immunology
MH  - Placentation
MH  - *Polymorphism, Genetic
MH  - Pre-Eclampsia/genetics/immunology
MH  - Pregnancy
MH  - Sequence Deletion/genetics/immunology
MH  - Trophoblasts/*immunology
EDAT- 2004/06/29 05:00
MHDA- 2005/02/11 09:00
CRDT- 2004/06/29 05:00
PHST- 2004/01/08 00:00 [received]
PHST- 2004/03/16 00:00 [revised]
PHST- 2004/03/18 00:00 [accepted]
PHST- 2004/06/29 05:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2004/06/29 05:00 [entrez]
AID - S0198885904000801 [pii]
AID - 10.1016/j.humimm.2004.03.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Jun;65(6):586-93. doi: 10.1016/j.humimm.2004.03.002.