PMID- 15219383
OWN - NLM
STAT- MEDLINE
DCOM- 20050210
LR  - 20221207
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 65
IP  - 6
DP  - 2004 Jun
TI  - Association of tumor necrosis factor and human leukocyte antigen DRB1 alleles 
      with Graves' ophthalmopathy.
PG  - 632-9
AB  - Tumor necrosis factor (TNF)-alpha plays a central role in the development of 
      ophthalmopathy in patients with Graves' disease (GD). The aim of this study was 
      to investigate the association of TNF promoter polymorphisms at positions -1031 
      (T-1031C), -863 (C-863A), -857 (C-857T), -308 (G-308A), and -238 (G-238A) with 
      Graves' ophthalmopathy (GO). We studied the distribution of TNF and human 
      leukocyte antigen (HLA) DRB1 alleles in 228 Polish white patients with GD, 106 of 
      whom had ophthalmopathy (NOSPECS class > or = III) and 248 healthy subjects. TNF 
      -308A and HLA-DRB1*03 alleles were significantly increased in patients with GD 
      compared with healthy subjects. Stratification analysis revealed no independent 
      association of -308A with GD when the DRB1*03 status was considered. Subdividing 
      GD according to eye involvement revealed that the distribution of TNF promoter 
      haplotypes differed significantly in patients with or without ophthalmopathy. The 
      haplotype containing the -238A allele was absent in GO. The association of G-238A 
      with GO was independent of DRB1 alleles. These results indicate that TNF G-308A 
      is associated with susceptibility to GD (however, this association is not 
      independent of HLA-DRB1*03) and that TNF G-238A is associated with the 
      development of ophthalmopathy, suggesting that G-238A or a gene in linkage 
      disequilibrium may be disease modifying in GD.
FAU - Bednarczuk, Tomasz
AU  - Bednarczuk T
AD  - Department of Endocrinology, Medical Research Center in Warsaw, Poland. 
      bernar@amwaw.edu.pl
FAU - Hiromatsu, Yuji
AU  - Hiromatsu Y
FAU - Seki, Naoko
AU  - Seki N
FAU - Ploski, Rafal
AU  - Ploski R
FAU - Fukutani, Tomoka
AU  - Fukutani T
FAU - Kurylowicz, Alina
AU  - Kurylowicz A
FAU - Jazdzewski, Krystian
AU  - Jazdzewski K
FAU - Chojnowski, Krzysztof
AU  - Chojnowski K
FAU - Itoh, Kyogo
AU  - Itoh K
FAU - Nauman, Janusz
AU  - Nauman J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Graves Disease/*genetics/pathology
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes/genetics
MH  - Humans
MH  - Linkage Disequilibrium/genetics
MH  - Male
MH  - Poland
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Promoter Regions, Genetic/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - White People
EDAT- 2004/06/29 05:00
MHDA- 2005/02/11 09:00
CRDT- 2004/06/29 05:00
PHST- 2003/12/16 00:00 [received]
PHST- 2004/02/13 00:00 [revised]
PHST- 2004/02/19 00:00 [accepted]
PHST- 2004/06/29 05:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2004/06/29 05:00 [entrez]
AID - S0198885904000771 [pii]
AID - 10.1016/j.humimm.2004.02.033 [doi]
PST - ppublish
SO  - Hum Immunol. 2004 Jun;65(6):632-9. doi: 10.1016/j.humimm.2004.02.033.