PMID- 15219596
OWN - NLM
STAT- MEDLINE
DCOM- 20040916
LR  - 20220331
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 22
IP  - 3
DP  - 2004 Jul
TI  - An fMRI study of differential neural response to affective pictures in 
      schizophrenia.
PG  - 1247-54
AB  - Although emotional dysfunction is considered a fundamental symptom of 
      schizophrenia, studies investigating the neural basis of emotional dysfunction in 
      schizophrenia are few. Using functional magnetic resonance imaging (fMRI) and a 
      task viewing affective pictures, we aimed to examine automatic emotional response 
      and to elucidate the neural basis of impaired emotional processing in 
      schizophrenia. Fifteen healthy volunteers and 15 schizophrenics were studied. 
      During the scans, the subjects were instructed to indicate how each of the 
      presented pictures made them feel. Whole brain activities in response to the 
      affective pictures were measured by fMRI. Controls recruited the neural circuit 
      including amygdaloid-hippocampal region, prefrontal cortex, thalamus, basal 
      ganglia, cerebellum, midbrain, and visual cortex while viewing unpleasant 
      pictures. Despite an equal behavioral result to controls, the patients showed 
      less activation in the components of the circuit (right amygdala, bilateral 
      hippocampal region, medial prefrontal cortex (MPFC), basal ganglia, thalamus, 
      cerebellum, midbrain, and visual cortex). This study demonstrated functional 
      abnormalities in the neural circuit of emotional processing in schizophrenia. In 
      particular, decreased activation in the right amygdala and MPFC appears to be an 
      important finding related to dysfunctional emotional behavior in schizophrenia.
CI  - Copyright 2004 Elsevier Inc.
FAU - Takahashi, Hidehiko
AU  - Takahashi H
AD  - Section of Psychiatry and Behavioral Science, Graduate School of Medicine, Tokyo 
      Medical and Dental University, Japan.
FAU - Koeda, Michihiko
AU  - Koeda M
FAU - Oda, Kenji
AU  - Oda K
FAU - Matsuda, Tetsuya
AU  - Matsuda T
FAU - Matsushima, Eisuke
AU  - Matsushima E
FAU - Matsuura, Masato
AU  - Matsuura M
FAU - Asai, Kunihiko
AU  - Asai K
FAU - Okubo, Yoshiro
AU  - Okubo Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - *Affect
MH  - Amygdala/physiopathology
MH  - Brain/*physiopathology
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Oxygen/blood
MH  - Prefrontal Cortex/physiopathology
MH  - Schizophrenia/blood/*diagnosis/*physiopathology
MH  - *Schizophrenic Psychology
MH  - Self Concept
EDAT- 2004/06/29 05:00
MHDA- 2004/09/17 05:00
CRDT- 2004/06/29 05:00
PHST- 2003/11/20 00:00 [received]
PHST- 2004/01/24 00:00 [revised]
PHST- 2004/03/08 00:00 [accepted]
PHST- 2004/06/29 05:00 [pubmed]
PHST- 2004/09/17 05:00 [medline]
PHST- 2004/06/29 05:00 [entrez]
AID - S1053811904001673 [pii]
AID - 10.1016/j.neuroimage.2004.03.028 [doi]
PST - ppublish
SO  - Neuroimage. 2004 Jul;22(3):1247-54. doi: 10.1016/j.neuroimage.2004.03.028.