PMID- 15220823
OWN - NLM
STAT- MEDLINE
DCOM- 20041223
LR  - 20191108
IS  - 1072-4109 (Print)
IS  - 1072-4109 (Linking)
VI  - 11
IP  - 4
DP  - 2004 Jul
TI  - Pancreatic endocrine tumors: an update.
PG  - 202-10
AB  - The morphology of pancreatic endocrine tumors (PETs) is similar to that of 
      endocrine tumors elsewhere in the body. PETs are usually encountered in adults. 
      They may be clinically functional and associated with various syndromes related 
      to hormone excess. However, it must be remembered that absence of obvious 
      clinical symptoms may not necessarily reflect true lack of clinical function, and 
      subtle clinical manifestations may be missed. Current thinking indicates that 
      PETs arise from totipotential stem cells as well as preexisting endocrine cells. 
      PETs may be hereditary or sporadic. The hereditary forms are associated with 
      multiple endocrine neoplasia type 1 (MEN-1), von Hippel-Lindau syndrome, 
      neurofibromatosis, and tuberous sclerosis. In sporadic PETs, the most consistent 
      and recurring chromosomal abnormality is allelic loss of chromosome 11q, which 
      includes the MEN-1 locus. Loss of a sex chromosome has been shown to be 
      associated with metastasis, local invasion, and poor survival.
FAU - Chetty, Runjan
AU  - Chetty R
AD  - Department of Pathology, University Health Network/Toronto Medical Laboratories, 
      University of Toronto, Toronto, Canada.
FAU - Asa, Sylvia L
AU  - Asa SL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Anat Pathol
JT  - Advances in anatomic pathology
JID - 9435676
SB  - IM
MH  - Adult
MH  - *Endocrine Gland Neoplasms
MH  - Humans
MH  - *Pancreatic Neoplasms
RF  - 60
EDAT- 2004/06/29 05:00
MHDA- 2004/12/24 09:00
CRDT- 2004/06/29 05:00
PHST- 2004/06/29 05:00 [pubmed]
PHST- 2004/12/24 09:00 [medline]
PHST- 2004/06/29 05:00 [entrez]
AID - 00125480-200407000-00003 [pii]
AID - 10.1097/01.pap.0000131828.00189.29 [doi]
PST - ppublish
SO  - Adv Anat Pathol. 2004 Jul;11(4):202-10. doi: 10.1097/01.pap.0000131828.00189.29.