PMID- 15221082
OWN - NLM
STAT- MEDLINE
DCOM- 20041222
LR  - 20211203
IS  - 0020-9554 (Print)
IS  - 0020-9554 (Linking)
VI  - 45
IP  - 8
DP  - 2004 Aug
TI  - [Immune restoration inflammatory syndromes].
PG  - 893-903
AB  - Increase of prevalence of certain immunodeficiencies is caused by more frequent 
      use of immunosuppresive treatment, by advances in supportive care of 
      immunodeficient individuals and by the pandemic spread of HIV-infection 
      respectively. Highly active antiretroviral treatment (HAART) is able to 
      reconstitute the impaired immunity in the HIV-infected individual and therefore 
      to reduce morbidity and mortality. On the other hand paradoxical exacerbation of 
      inflammatory or opportunistic diseases may develop during immunoreconstitution. 
      By their distinct pathophysiological, clinical and therapeutic particularities 
      these disease have been summarized as Immune Restoration Inflammatory Syndromes 
      (IRIS). This review summarizes the variety of immunoreconstitution disorders and 
      describes possible diagnostic pitfalls. Potential therapeutic options and an 
      algorithm for the classification of the syndrome are proposed.
FAU - Stoll, M
AU  - Stoll M
AD  - Abteilung Klinische Immunologie, Medizinische Hochschule Hannover. 
      stoll.matthias@mh-hannover.de
FAU - Heiken, H
AU  - Heiken H
FAU - Behrens, G M N
AU  - Behrens GM
FAU - Schmidt, R E
AU  - Schmidt RE
LA  - ger
PT  - Journal Article
PT  - Review
TT  - Immunrekonstitutionssyndrome (IRIS). Ein scheinbares Paradoxon.
PL  - Germany
TA  - Internist (Berl)
JT  - Der Internist
JID - 0264620
SB  - IM
MH  - Algorithms
MH  - Diagnosis, Differential
MH  - HIV Infections/therapy
MH  - Humans
MH  - Immunologic Deficiency Syndromes/diagnosis/immunology/*therapy
MH  - Immunosuppression Therapy/adverse effects
MH  - Immunotherapy/*adverse effects
MH  - Opportunistic Infections/diagnosis/etiology/immunology
MH  - Risk Factors
MH  - Systemic Inflammatory Response Syndrome/diagnosis/*etiology/immunology
RF  - 55
EDAT- 2004/06/29 05:00
MHDA- 2004/12/23 09:00
CRDT- 2004/06/29 05:00
PHST- 2004/06/29 05:00 [pubmed]
PHST- 2004/12/23 09:00 [medline]
PHST- 2004/06/29 05:00 [entrez]
AID - 10.1007/s00108-004-1229-0 [doi]
PST - ppublish
SO  - Internist (Berl). 2004 Aug;45(8):893-903. doi: 10.1007/s00108-004-1229-0.