PMID- 15221201
OWN - NLM
STAT- MEDLINE
DCOM- 20050323
LR  - 20181113
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 177
IP  - 1-2
DP  - 2004 Dec
TI  - Functional MRI study of working memory in MDMA users.
PG  - 185-94
AB  - RATIONALE: Methylene-dioxymethamphetamine (MDMA) is known to cause degeneration 
      of serotonin nerve terminals after acute doses in animals. Similarly, behavioral 
      studies in human MDMA users regularly find abnormalities in memory, mood, and 
      impulse control. However, studies of brain function using brain imaging in MDMA 
      users have been less consistent. OBJECTIVES: The purpose of this study was to 
      determine, using functional magnetic resonance imaging (fMRI), whether 
      individuals with a self-reported history of MDMA use would differ from non-MDMA 
      using controls on activation while performing a working memory task. METHODS: 
      Fifteen MDMA using subjects and 19 non-MDMA using controls underwent fMRI 
      scanning while performing the immediate and delayed memory task (IMT/DMT). The 
      study was based on a block design in which the delayed memory task (DMT) 
      alternated with the immediate memory task (IMT), which served as a control 
      condition. FMRI scans were acquired on a 1.5 T scanner, using a gradient echo 
      echoplanar pulse sequence. RESULTS: Random effects SPM99 analysis showed 
      significantly greater activation (whole volume corrected cluster P<0.05) during 
      the DMT relative to the IMT in the MDMA subjects compared with the control 
      subjects in the medial superior frontal gyrus, in the thalamus extending into 
      putamen, and in the hippocampus. CONCLUSIONS: Although these effects could be due 
      to other drugs used by MDMA users, these results are consistent with behavioral 
      problems that are associated with MDMA use, and with animal studies on the 
      effects of MDMA on brain function.
FAU - Moeller, F Gerard
AU  - Moeller FG
AD  - Department of Psychiatry and Behavioral Sciences, University of Texas Health 
      Science Center Houston, 1300 Moursund, Houston, TX 77030, USA. 
      frederick.g.moeller@uth.tmc.edu
FAU - Steinberg, Joel L
AU  - Steinberg JL
FAU - Dougherty, Donald M
AU  - Dougherty DM
FAU - Narayana, Ponnada A
AU  - Narayana PA
FAU - Kramer, Larry A
AU  - Kramer LA
FAU - Renshaw, Perry F
AU  - Renshaw PF
LA  - eng
GR  - K02-DA00403/DA/NIDA NIH HHS/United States
GR  - R01-DA08425/DA/NIDA NIH HHS/United States
GR  - R01-DA15345/DA/NIDA NIH HHS/United States
GR  - R01-MH61927/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20040618
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Memory/drug effects/*physiology
MH  - *N-Methyl-3,4-methylenedioxyamphetamine/adverse effects
MH  - Psychomotor Performance/*physiology
MH  - Substance-Related Disorders/*physiopathology
EDAT- 2004/06/29 05:00
MHDA- 2005/03/24 09:00
CRDT- 2004/06/29 05:00
PHST- 2004/02/03 00:00 [received]
PHST- 2004/04/07 00:00 [accepted]
PHST- 2004/06/29 05:00 [pubmed]
PHST- 2005/03/24 09:00 [medline]
PHST- 2004/06/29 05:00 [entrez]
AID - 10.1007/s00213-004-1908-5 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2004 Dec;177(1-2):185-94. doi: 
      10.1007/s00213-004-1908-5. Epub 2004 Jun 18.