PMID- 1522224
OWN - NLM
STAT- MEDLINE
DCOM- 19921013
LR  - 20181113
IS  - 0021-9738 (Print)
IS  - 0021-9738 (Linking)
VI  - 90
IP  - 3
DP  - 1992 Sep
TI  - Hypertrophic gastropathy resembling Menetrier's disease in transgenic mice 
      overexpressing transforming growth factor alpha in the stomach.
PG  - 1161-7
AB  - Transforming growth factor alpha (TGF alpha) is thought to participate in the 
      normal and pathologic processes of numerous tissues, including the gastric 
      mucosa. To explore its role in vivo, transgenic mice were generated 
      overexpressing TGF alpha in the stomach. TGF alpha induced dramatic structural 
      and functional lesions of the glandular stomach that were similar to Menetrier's 
      disease in humans. Transgenic mice developed severe adenomatous hyperplasia that 
      resulted in a striking nodular thickening or hypertrophy of the gastric mucosa. 
      Secretions obtained from affected stomachs contained no detectable gastric acid, 
      suggesting that parietal cell function had been greatly impaired. These findings 
      demonstrate that overproduction of TGF alpha can stimulate cellular 
      proliferation, suppress acid secretion, and perturb organogenesis of the stomach 
      of transgenic mice. Moreover, TGF alpha may contribute to the pathogenesis of 
      related human hypertrophic gastropathies, such as Menetrier's disease.
FAU - Takagi, H
AU  - Takagi H
AD  - Laboratory of Molecular Biology, National Cancer Institute, National Institutes 
      of Health, Bethesda, Maryland 20892.
FAU - Jhappan, C
AU  - Jhappan C
FAU - Sharp, R
AU  - Sharp R
FAU - Merlino, G
AU  - Merlino G
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Transforming Growth Factor alpha)
SB  - IM
MH  - Animals
MH  - Gastric Mucosa/*pathology
MH  - Gastritis, Hypertrophic/*metabolism/pathology
MH  - Hypertrophy
MH  - Mice
MH  - Mice, Transgenic
MH  - Transforming Growth Factor alpha/*biosynthesis/genetics
PMC - PMC329980
EDAT- 1992/09/01 00:00
MHDA- 1992/09/01 00:01
PMCR- 1992/09/01
CRDT- 1992/09/01 00:00
PHST- 1992/09/01 00:00 [pubmed]
PHST- 1992/09/01 00:01 [medline]
PHST- 1992/09/01 00:00 [entrez]
PHST- 1992/09/01 00:00 [pmc-release]
AID - 10.1172/JCI115936 [doi]
PST - ppublish
SO  - J Clin Invest. 1992 Sep;90(3):1161-7. doi: 10.1172/JCI115936.