PMID- 15223061
OWN - NLM
STAT- MEDLINE
DCOM- 20041022
LR  - 20081121
IS  - 0966-842X (Print)
IS  - 0966-842X (Linking)
VI  - 12
IP  - 7
DP  - 2004 Jul
TI  - Virus infection of dendritic cells: portal for host invasion and host defense.
PG  - 337-45
AB  - Dendritic cells (DCs) act as a portal for virus invasion and as the most potent 
      antigen-presenting cells in antiviral host defense. Human immunodeficiency virus 
      (HIV)-1 has served as the paradigm for virus interaction with DCs. HIV-1 
      infection of DCs via its primary CD4 receptor and secondary chemokine receptors 
      leads to full virus replication (cis infection), whereas binding to C-type lectin 
      receptors results both in cis replication, as well as transfer and replication of 
      virus in CD4(pos) T cells (trans infection). DCs respond to this invasion by 
      processing viral proteins through MHC class I and II pathways and undergoing a 
      maturation that enhances their presentation of antigen to T cells for induction 
      of adaptive antiviral immunity. HIV-1 and other viruses have evolved mechanisms 
      to subvert this immune function. Engineering of DCs with various forms of viral 
      immunogens and co-treatment with cytokines and chemokines is being used as an 
      immunotherapy for HIV-1 and other viral infections.
FAU - Rinaldo, Charles R Jr
AU  - Rinaldo CR Jr
AD  - Department of Infectious Diseases and Microbiology and Department of Pathology, 
      University of Pittsburgh, Pittsburgh, PA 15261, USA. rinaldo@pitt.edu
FAU - Piazza, Paolo
AU  - Piazza P
LA  - eng
GR  - R01 AI 41780/AI/NIAID NIH HHS/United States
GR  - U01 AI 35041/AI/NIAID NIH HHS/United States
GR  - U01 AI 37984/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Trends Microbiol
JT  - Trends in microbiology
JID - 9310916
RN  - 0 (Receptors, Virus)
SB  - IM
EIN - Trends Microbiol. 2004 Nov;12(11):483
MH  - Animals
MH  - Antigen Presentation
MH  - Dendritic Cells/*immunology/*virology
MH  - HIV-1/immunology/pathogenicity/physiology
MH  - Hepatitis Viruses/immunology/pathogenicity/physiology
MH  - Herpesviridae/immunology/pathogenicity/physiology
MH  - Humans
MH  - Measles virus/growth & development/immunology/pathogenicity
MH  - Receptors, Virus/*physiology
MH  - *Virus Physiological Phenomena
MH  - Viruses/immunology/pathogenicity
RF  - 83
EDAT- 2004/06/30 05:00
MHDA- 2004/10/23 09:00
CRDT- 2004/06/30 05:00
PHST- 2004/06/30 05:00 [pubmed]
PHST- 2004/10/23 09:00 [medline]
PHST- 2004/06/30 05:00 [entrez]
AID - S0966842X04001131 [pii]
AID - 10.1016/j.tim.2004.05.003 [doi]
PST - ppublish
SO  - Trends Microbiol. 2004 Jul;12(7):337-45. doi: 10.1016/j.tim.2004.05.003.