PMID- 15225672
OWN - NLM
STAT- MEDLINE
DCOM- 20050208
LR  - 20220316
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 50
IP  - 3
DP  - 2004 Sep
TI  - The effects of erdosteine on the activities of some metabolic enzymes during 
      cisplatin-induced nephrotoxicity in rats.
PG  - 287-90
AB  - Cisplatin is one of the widely used chemothrapeutic agents. One of the major side 
      effects of the drug is renal toxicity. The aims of the presented study was (1) to 
      investigate the effect of cisplatin on some renal metabolic enzyme activities 
      such as hexokinase (HK), glucose-6-phosphate dehydrogenase (G6PD), lactate 
      dehydrogenase (LDH), and malate dehydrogenase (MDH) in an experimental model of 
      acute renal failure and (2) to examine the protective role of erdosteine, an 
      expectorant agent which has also antioxidant properties on cisplatin-induced 
      nephrotoxicity and the enzyme activities mentioned above. Female Wistar albino 
      rats were divided into three groups: sham operation group (n = 6), cisplatin 
      group ( n = 9), erdostein + cisplatin group ( n = 8). All the chemicals used were 
      applied intraperitoneally. Hexokinase, G6PD, LDH, and MDH activities were 
      determined in the kidney supernatant at the end of the surgical procedures. 
      Spectrophotometric methods were used to determine the activities of 
      above-mentioned enzymes in the kidney tissue. Hexokinase and G6PD activities were 
      found to be increased in cisplatin group compared to control group. G6PD 
      activities were found to be decreased in erdosteine + cisplatin group compared to 
      cisplatin group. There were minimal changes in LDH and MDH activities of the two 
      study groups compared with the control group. The results obtained suggested that 
      the glucose metabolizing metabolic pathways of renal tissue were partially 
      affected from cisplatin toxicity and erdosteine have some protective effects on 
      these enzyme activities.
FAU - Yilmaz, H Ramazan
AU  - Yilmaz HR
AD  - Department of Medical Biology and Genetics, Faculty of Medicine, Suleyman Demirel 
      University, 32260 Isparta, Turkey. hramazany@yahoo.com
FAU - Iraz, Mustafa
AU  - Iraz M
FAU - Sogut, Sadik
AU  - Sogut S
FAU - Ozyurt, Huseyin
AU  - Ozyurt H
FAU - Yildirim, Zeki
AU  - Yildirim Z
FAU - Akyol, Omer
AU  - Akyol O
FAU - Gergerlioglu, Serdar
AU  - Gergerlioglu S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Thioglycolates)
RN  - 0 (Thiophenes)
RN  - 76J0853EKA (erdosteine)
RN  - EC 1.1.1.37 (Malate Dehydrogenase)
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Animals
MH  - Cisplatin/*toxicity
MH  - Glucosephosphate Dehydrogenase/metabolism
MH  - Kidney/*drug effects/*enzymology
MH  - Malate Dehydrogenase/metabolism
MH  - Rats
MH  - Renal Insufficiency/chemically induced/*enzymology/prevention & control
MH  - Thioglycolates/*pharmacology/therapeutic use
MH  - Thiophenes/*pharmacology/therapeutic use
EDAT- 2004/07/01 05:00
MHDA- 2005/02/09 09:00
CRDT- 2004/07/01 05:00
PHST- 2004/03/01 00:00 [accepted]
PHST- 2004/07/01 05:00 [pubmed]
PHST- 2005/02/09 09:00 [medline]
PHST- 2004/07/01 05:00 [entrez]
AID - S1043661804000635 [pii]
AID - 10.1016/j.phrs.2004.03.003 [doi]
PST - ppublish
SO  - Pharmacol Res. 2004 Sep;50(3):287-90. doi: 10.1016/j.phrs.2004.03.003.