PMID- 15226477
OWN - NLM
STAT- MEDLINE
DCOM- 20040810
LR  - 20230216
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 134
IP  - 7
DP  - 2004 Jul
TI  - Hyperhomocysteinemia in healthy young men and elderly men with normal serum 
      folate concentration is not associated with poor vascular reactivity or oxidative 
      stress.
PG  - 1832-5
AB  - The mechanism by which homocysteine (Hcy) causes endothelial dysfunction is 
      probably mediated by oxidative stress. The aim of this study was to evaluate the 
      effect of oxidative stress on endothelial function in young and elderly 
      hyperhomocysteinemic (HHcy) men. A total of 35 HHcy (Hcy > 15 micro mol/L), young 
      (n = 15; 20-40 y) and elderly men (n = 20; > 65 y) and 33 normohomocysteinemic 
      (NHcy; controls) young (n = 14) and elderly (n = 19) men (Hcy < 13 micro mol/L), 
      without classic cardiovascular risk factors were recruited. Serum Hcy, folate, 
      and vitamin B-12, whole-blood glutathione, plasma total antioxidants status, 
      TBARS, and 8-F(2alpha) isoprostanes were determined. Noninvasive ultrasound 
      measurements of endothelium-dependent (EDVR) and -independent dilatation (EIVR) 
      were performed. EDVR, EIVR, and markers of oxidative stress did not differ among 
      the groups. Folate concentrations were higher in elderly than in young men (P < 
      0.001), independent of Hcy concentrations. Vitamin B-12 concentrations were lower 
      in HHcy than in NHcy elderly men (P < 0.045). EDVR was correlated with folate 
      concentrations in young men (r = 0.40, P = 0.04) and negatively with BMI in 
      elderly men (r = -0.52, P = 0.002). In the present study, HHcy with normal serum 
      folate concentrations was not associated with poor EDVR or oxidative stress in 
      healthy young and elderly men.
FAU - Hirsch, Sandra
AU  - Hirsch S
AD  - Institute of Nutrition and Food Technology, University of Chile and. Clinica 
      Santa Maria, Santiago, Chile. shirsch@inta.cl
FAU - Ronco, Ana Maria
AU  - Ronco AM
FAU - Vasquez, Marcela
AU  - Vasquez M
FAU - de la Maza, Maria Pia
AU  - de la Maza MP
FAU - Garrido, Argelia
AU  - Garrido A
FAU - Barrera, Gladys
AU  - Barrera G
FAU - Gattas, Vivien
AU  - Gattas V
FAU - Glasinovic, Andrea
AU  - Glasinovic A
FAU - Leiva, Laura
AU  - Leiva L
FAU - Bunout, Daniel
AU  - Bunout D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Antioxidants)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aging/*blood
MH  - Antioxidants/metabolism
MH  - Endothelium, Vascular/physiology
MH  - Folic Acid/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Male
MH  - *Oxidative Stress
MH  - *Vasodilation
EDAT- 2004/07/01 05:00
MHDA- 2004/08/11 05:00
CRDT- 2004/07/01 05:00
PHST- 2004/07/01 05:00 [pubmed]
PHST- 2004/08/11 05:00 [medline]
PHST- 2004/07/01 05:00 [entrez]
AID - S0022-3166(23)02953-X [pii]
AID - 10.1093/jn/134.7.1832 [doi]
PST - ppublish
SO  - J Nutr. 2004 Jul;134(7):1832-5. doi: 10.1093/jn/134.7.1832.