PMID- 15226634
OWN - NLM
STAT- MEDLINE
DCOM- 20050415
LR  - 20190819
IS  - 1346-9843 (Print)
IS  - 1346-9843 (Linking)
VI  - 68
IP  - 7
DP  - 2004 Jul
TI  - Significance of the level of monocyte chemoattractant protein-1 in human 
      atherosclerosis.
PG  - 671-6
AB  - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1), a potent chemoattractant 
      for monocytes, plays an important role in the earliest events of atherogenesis. 
      However, direct evidence of the effects of MCP-1 on atherosclerosis in chronic 
      hemodialysis (HD) patients has not been reported. METHODS AND RESULTS: The serum 
      MCP-1 concentrations and the intimal - medial thickness (IMT) in the carotid 
      arteries were measured in 42 non-diabetic chronic HD patients and 20 age-matched 
      controls. The expression of MCP-1 was examined immunohistochemically in radial 
      arterial tissues obtained from the HD patients. IMT and the serum concentration 
      of MCP-1 in the HD patients were both significantly greater than in controls. 
      Multiple regression analysis revealed that the serum concentration of MCP-1 was 
      an independent factor influencing IMT. Tissue immunostaining showed that MCP-1 is 
      expressed in both endothelial and smooth muscle cells and that its level of 
      expression correlates with the serum concentration of MCP-1. CONCLUSIONS: An 
      increase in MCP-1 may be an important factor in the progression of 
      atherosclerosis in non-diabetic HD patients.
FAU - Kusano, Kengo Fukushima
AU  - Kusano KF
AD  - Department of Cardiovascular Medicine, Okayama University Graduate School of 
      Medicine and Dentistry, Okayama, Japan. kfuku0218@aol.com
FAU - Nakamura, Kazufumi
AU  - Nakamura K
FAU - Kusano, Hitoshi
AU  - Kusano H
FAU - Nishii, Nobuhiro
AU  - Nishii N
FAU - Banba, Kimikazu
AU  - Banba K
FAU - Ikeda, Tetsuya
AU  - Ikeda T
FAU - Hashimoto, Katsushi
AU  - Hashimoto K
FAU - Yamamoto, Mika
AU  - Yamamoto M
FAU - Fujio, Hideki
AU  - Fujio H
FAU - Miura, Aya
AU  - Miura A
FAU - Ohta, Keiko
AU  - Ohta K
FAU - Morita, Hiroshi
AU  - Morita H
FAU - Saito, Hironori
AU  - Saito H
FAU - Emori, Tetsuro
AU  - Emori T
FAU - Nakamura, Yoichi
AU  - Nakamura Y
FAU - Kusano, Isao
AU  - Kusano I
FAU - Ohe, Tohru
AU  - Ohe T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arteriosclerosis/*blood/epidemiology
MH  - Carotid Stenosis/epidemiology
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/complications
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - *Renal Dialysis
MH  - Risk Factors
MH  - Smoking
EDAT- 2004/07/01 05:00
MHDA- 2005/04/16 09:00
CRDT- 2004/07/01 05:00
PHST- 2004/07/01 05:00 [pubmed]
PHST- 2005/04/16 09:00 [medline]
PHST- 2004/07/01 05:00 [entrez]
AID - 10.1253/circj.68.671 [doi]
PST - ppublish
SO  - Circ J. 2004 Jul;68(7):671-6. doi: 10.1253/circj.68.671.