PMID- 15230817
OWN - NLM
STAT- MEDLINE
DCOM- 20050210
LR  - 20131121
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 59
IP  - 8
DP  - 2004 Aug
TI  - Association study of polymorphisms within interleukin-18 in juvenile idiopathic 
      arthritis and bronchial asthma.
PG  - 845-9
AB  - BACKGROUND: Interleukin-18 (IL-18) plays an important role in the regulation of 
      TH1 as well as TH2 immunologic responses and thus in the development of chronic 
      inflammatory diseases. Positive association studies of polymorphisms in IL-18 
      with different diseases have underlined the involvement of IL-18 in the 
      pathogenetics processes. Our interest was to test polymorphisms of IL-18 for 
      association with a typical TH1-mediated disease--juvenile idiopathic 
      arthritis--and the TH2-mediated disease bronchial asthma in Caucasian children. 
      METHODS: We genotyped five polymorphisms that were in association with chronic 
      inflammatory diseases (-607C, -137C, 113G, 127T, and -133G). This was performed 
      by restriction fragment length polymorphism in populations of asthmatic children, 
      control individuals, and children with antinuclear antibodies (ANA)-positive 
      juvenile idiopathic arthritis. Statistical analysis was performed by the Armitage 
      trend test; haplotypes were calculated by the Arlequine program. RESULTS: No 
      significant association was found between any single nucleotide polymorphism or 
      any haplotype and bronchial asthma or ANA-positive juvenile idiopathic arthritis. 
      CONCLUSION: We conclude that the effect of IL-18 in the immunologic context of 
      diseases like bronchial asthma or juvenile arthritis might be too complex to be 
      reflected in a simple one-way association study. Furthermore, the polymorphisms 
      under investigation might be nonfunctional.
FAU - Heinzmann, A
AU  - Heinzmann A
AD  - University Children's Hospital, University of Freiburg, Mathildenstrasse 1, 79106 
      Freiburg, Germany.
FAU - Gerhold, K
AU  - Gerhold K
FAU - Ganter, K
AU  - Ganter K
FAU - Kurz, T
AU  - Kurz T
FAU - Schuchmann, L
AU  - Schuchmann L
FAU - Keitzer, R
AU  - Keitzer R
FAU - Berner, R
AU  - Berner R
FAU - Deichmann, K A
AU  - Deichmann KA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Adolescent
MH  - Arthritis, Juvenile/*genetics/immunology
MH  - Asthma/*genetics/immunology
MH  - Child
MH  - Child, Preschool
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - *Polymorphism, Genetic
MH  - Th2 Cells/immunology
EDAT- 2004/07/03 05:00
MHDA- 2005/02/11 09:00
CRDT- 2004/07/03 05:00
PHST- 2004/07/03 05:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2004/07/03 05:00 [entrez]
AID - ALL538 [pii]
AID - 10.1111/j.1398-9995.2004.00538.x [doi]
PST - ppublish
SO  - Allergy. 2004 Aug;59(8):845-9. doi: 10.1111/j.1398-9995.2004.00538.x.