PMID- 15232666
OWN - NLM
STAT- MEDLINE
DCOM- 20050111
LR  - 20181113
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 158
IP  - 4
DP  - 2004 Oct
TI  - Effects of motor cortical stimulation on the excitability of contralateral motor 
      and sensory cortices.
PG  - 519-26
AB  - Single pulses of transcranial magnetic stimulation (TMS) were applied to the 
      right hemisphere over either the hand sensory area, the hand motor area (M1), 
      ventral premotor area (vPM), dorsolateral prefrontal cortex, or 10 cm away from 
      head (sham stimulation) in order to test the effect on motor evoked potentials 
      (MEPs) elicited by single pulse TMS or transcranial electrical stimulus (TES) 
      over the left M1 or the somatosensory evoked potential (SEP) elicited by an 
      electrical stimulus to the right median nerve. The interstimulus intervals (ISIs) 
      for MEP experiments were 50, 100, 150, 200, 300 and 400 ms, with those for SEP 
      experiments being adjusted for the impulse conduction time from the wrist to the 
      cortex. TMS over the right M1 reduced MEPs elicited by TMS of the left motor 
      cortex at ISIs of 50-150 ms, whereas MEPs produced by TES were unaffected. TMS 
      over M1 and vPM facilitated the contralateral cortical median nerve SEPs at an 
      ISI of 100-200 ms, whereas it had no effect on tibial nerve SEPs or paired median 
      nerve stimulation SEP. Based on these results, we conclude that at around 150-ms 
      intervals, TMS over the motor areas (M1 and vPM) reduces the excitability of the 
      contralateral motor area. This has a secondary effect of enhancing the 
      responsiveness of the sensory cortex through cortico-cortical connections.
FAU - Mochizuki, Hitoshi
AU  - Mochizuki H
AD  - Department of Neurology, Division of Neuroscience, Graduate School of Medicine, 
      University of Tokyo, 7-3-1 Hongo Bunkyo-ku, 113-8655 Tokyo, Japan.
FAU - Terao, Yasuo
AU  - Terao Y
FAU - Okabe, Shingo
AU  - Okabe S
FAU - Furubayashi, Toshiaki
AU  - Furubayashi T
FAU - Arai, Noritoshi
AU  - Arai N
FAU - Iwata, Nobue K
AU  - Iwata NK
FAU - Hanajima, Ritsuko
AU  - Hanajima R
FAU - Kamakura, Keiko
AU  - Kamakura K
FAU - Motoyoshi, Kazuo
AU  - Motoyoshi K
FAU - Ugawa, Yoshikazu
AU  - Ugawa Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040701
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Evoked Potentials, Motor/*physiology
MH  - Evoked Potentials, Somatosensory/*physiology
MH  - Female
MH  - Functional Laterality/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Motor Cortex/*physiology
MH  - Somatosensory Cortex/*physiology
EDAT- 2004/07/03 05:00
MHDA- 2005/01/12 09:00
CRDT- 2004/07/03 05:00
PHST- 2003/10/27 00:00 [received]
PHST- 2004/03/16 00:00 [accepted]
PHST- 2004/07/03 05:00 [pubmed]
PHST- 2005/01/12 09:00 [medline]
PHST- 2004/07/03 05:00 [entrez]
AID - 10.1007/s00221-004-1923-0 [doi]
PST - ppublish
SO  - Exp Brain Res. 2004 Oct;158(4):519-26. doi: 10.1007/s00221-004-1923-0. Epub 2004 
      Jul 1.