PMID- 15232839
OWN - NLM
STAT- MEDLINE
DCOM- 20040707
LR  - 20131121
IS  - 0023-7205 (Print)
IS  - 0023-7205 (Linking)
VI  - 101
IP  - 23
DP  - 2004 Jun 3
TI  - [Helicobacter pylori can in rare cases be the cause of iron and vitamin B 12 
      deficiency. No increased risk of iron and vitamin B 12 deficiency due to proton 
      pump inhibitors].
PG  - 2014-5
AB  - This article reviews iron and vitamin B12 malabsorption due to the use of proton 
      pump inhibitors (PPI) and infection with Helicobacter pylori. The bacterium is in 
      some studies associated with low serum values of both ferritin and cobalamin and 
      has in several cases been shown to cause reversible deficiency of these 
      nutrients. PPI depresses absorption of vitamin B12, but only one case of 
      deficiency has been reported in standard reflux therapy. Case reports exist of 
      PPI-related iron deficiency, but studies have not confirmed these risks. General 
      substitution with iron or B12 supplements in PPI therapy can't be advocated. The 
      safety of long-term use of PPI is well documented, but it is still unclear 
      whether PPI accelerates the development of atrophic corpus gastritis in the 
      presence of H pylori.
FAU - Mattsson, Niklas
AU  - Mattsson N
AD  - Sahlgrenska Universitetssjukhuset, Goteborg. mattsson_n@hotmail.com
FAU - Kilander, Anders
AU  - Kilander A
FAU - Bjornsson, Einar
AU  - Bjornsson E
LA  - swe
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Helicobacter pylori kan i sallsynta fall orsaka jarn- och vitamin B12-brist. 
      Ingen okad risk for jarn- eller B12-brist med protonpumpshammare.
PL  - Sweden
TA  - Lakartidningen
JT  - Lakartidningen
JID - 0027707
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anemia, Iron-Deficiency/chemically induced/*etiology/microbiology
MH  - Helicobacter Infections/*complications
MH  - Humans
MH  - *Proton Pump Inhibitors
MH  - Risk Factors
MH  - Vitamin B 12 Deficiency/chemically induced/*etiology/microbiology
RF  - 32
EDAT- 2004/07/06 05:00
MHDA- 2004/07/09 05:00
CRDT- 2004/07/06 05:00
PHST- 2004/07/06 05:00 [pubmed]
PHST- 2004/07/09 05:00 [medline]
PHST- 2004/07/06 05:00 [entrez]
PST - ppublish
SO  - Lakartidningen. 2004 Jun 3;101(23):2014-5.