PMID- 15234532
OWN - NLM
STAT- MEDLINE
DCOM- 20050209
LR  - 20081121
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 94
IP  - 1-2
DP  - 2004 Jun 15
TI  - Host genetic background determines whether IL-18 deficiency results in increased 
      susceptibility or resistance to murine Leishmania major infection.
PG  - 35-7
AB  - Interleukin-18 (IL-18) plays an important role in innate and acquired immunity. 
      IL-18 gene deficient (IL-18-/-) mice of the 129 x CD1 strain were reported to be 
      more susceptible to Leishmania major infection than the wild-type mice. In 
      contrast IL-18-/- mice of the C57BL/6 background were found to be as resistant as 
      the wild-type (WT) mice. To resolve this discrepancy, IL-18 gene deficiency was 
      introduced by backcrossing on to the highly susceptible BALB/c, or the moderately 
      resistant DBA/1 backgrounds. Here we have demonstrated that BALB/c IL-18-/- mice 
      were more resistant to L. major infection than WT BALB/c mice, whereas DBA/1 
      IL-18-/- mice were markedly more susceptible than their WT littermates. BALB/c 
      IL-18-/- mice produced less IFNgamma and IL-4, whereas DBA/1 IL-18ko mice 
      produced more IFNgamma and IL-4 than their respective WT controls. These result 
      clearly demonstrate that the role of IL-18 in resistance or susceptibility to L. 
      major is determined by host genetic background.
FAU - Wei, Xiao-Qing
AU  - Wei XQ
AD  - Division of Immunology, Infection and Inflammation, University of Glasgow, 
      Western Infirmary, Glasgow, Scotland G11 6NT, UK. xqw1r@clinmed.gla.ac.uk
FAU - Niedbala, Wanda
AU  - Niedbala W
FAU - Xu, Damo
AU  - Xu D
FAU - Luo, Zhao-Xia
AU  - Luo ZX
FAU - Pollock, Kevin G J
AU  - Pollock KG
FAU - Brewer, James M
AU  - Brewer JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Interleukin-18)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Disease Susceptibility/immunology
MH  - Interferon-gamma/analysis
MH  - Interleukin-18/*genetics
MH  - Interleukin-4/analysis
MH  - *Leishmania major
MH  - Leishmaniasis, Cutaneous/*genetics/immunology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Knockout
MH  - T-Lymphocytes/immunology
EDAT- 2004/07/06 05:00
MHDA- 2005/02/11 09:00
CRDT- 2004/07/06 05:00
PHST- 2004/02/13 00:00 [received]
PHST- 2004/04/08 00:00 [revised]
PHST- 2004/04/08 00:00 [accepted]
PHST- 2004/07/06 05:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2004/07/06 05:00 [entrez]
AID - S0165247804000896 [pii]
AID - 10.1016/j.imlet.2004.04.001 [doi]
PST - ppublish
SO  - Immunol Lett. 2004 Jun 15;94(1-2):35-7. doi: 10.1016/j.imlet.2004.04.001.