PMID- 15234542
OWN - NLM
STAT- MEDLINE
DCOM- 20050209
LR  - 20061115
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 94
IP  - 1-2
DP  - 2004 Jun 15
TI  - Down-regulation of dendritic cell activation induced by Paracoccidioides 
      brasiliensis.
PG  - 107-14
AB  - Paracoccidioidomycosis (PCM) endemic in Latin America, is a progressive systemic 
      mycosis caused by Paracoccidioides brasiliensis (Pb). The infection can evolve to 
      different clinical forms that are associated to various degrees of suppressed 
      cell-mediated immunity. With the recognition that DCs are able to initiate 
      response in naive T cells and that they also participate in Th cell education, 
      the present study was undertaken to check whether DCs interact with P. 
      brasiliensis, as well as to elucidate possible mechanisms and consequences of 
      this interaction. Our results indicate that P. brasiliensis infection and 
      purified gp43, its main antigenic component, lead to down-regulation of MHC-II 
      and adhesion properties of immature DCs. The down-regulation was also observed in 
      LPS-induced DC maturation. In addition, an inhibition of IL-12 and TNF-alpha 
      production by both P. brasileinsis or gp43, was observed in LPS-induced DC 
      maturation. These results suggest that protein, released in great amounts by the 
      fungus, might be used, to reduce the effectiveness of the immune response.
FAU - Ferreira, Karen Spadari
AU  - Ferreira KS
AD  - Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias 
      Farmaceuticas, Universidade de Sao Paulo, Avenida Prof. Lineu Prestes, 580, Bloco 
      17, CEP: 05508-900, Sao Paulo, Brazil.
FAU - Lopes, Jose Daniel
AU  - Lopes JD
FAU - Almeida, Sandro Rogerio
AU  - Almeida SR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (43 kDa protein, Paracoccidioides)
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Fungal)
RN  - 0 (Fungal Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Mannans)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Animals
MH  - Antigens, CD/metabolism
MH  - Antigens, Fungal/*pharmacology
MH  - Dendritic Cells/drug effects/immunology/*microbiology
MH  - Down-Regulation
MH  - Female
MH  - Fungal Proteins/*pharmacology
MH  - Glycoproteins/*pharmacology
MH  - Histocompatibility Antigens Class II/metabolism
MH  - Interleukin-12/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Mannans/pharmacology
MH  - Mice
MH  - Paracoccidioides/*pathogenicity
MH  - Paracoccidioidomycosis/metabolism
MH  - Phagocytosis/drug effects
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2004/07/06 05:00
MHDA- 2005/02/11 09:00
CRDT- 2004/07/06 05:00
PHST- 2004/02/05 00:00 [received]
PHST- 2004/04/08 00:00 [revised]
PHST- 2004/04/16 00:00 [accepted]
PHST- 2004/07/06 05:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2004/07/06 05:00 [entrez]
AID - S0165247804000938 [pii]
AID - 10.1016/j.imlet.2004.04.005 [doi]
PST - ppublish
SO  - Immunol Lett. 2004 Jun 15;94(1-2):107-14. doi: 10.1016/j.imlet.2004.04.005.