PMID- 15235224
OWN - NLM
STAT- MEDLINE
DCOM- 20040827
LR  - 20190724
IS  - 0031-6903 (Print)
IS  - 0031-6903 (Linking)
VI  - 124
IP  - 7
DP  - 2004 Jul
TI  - [DDS and Me].
PG  - 397-415
AB  - With the success of the human genome project, the focus of life science research 
      has shifted to the functional and structural analyses of proteins, such as 
      proteomics and structural genomics. These analyses of proteins including newly 
      identified proteins are expected to contribute to the identification of 
      therapeutically applicable proteins for various diseases. Thus, 
      pharmaco-proteomic-based drug discovery and development for protein therapies, 
      including gene therapy, cell therapy, and vaccine therapy, is attracting current 
      attention. However, there is clinical difficulty in using almost all bioactive 
      proteins, because of their very low stability and pleiotropic actions in vivo. To 
      promote pharmaco-proteomic-based drug discovery and development, we have 
      attempted to develop drug delivery systems (DDSs), such as the protein-drug 
      innovation system and the optimal cell therapeutic system. In this review, we 
      introduce our original DDSs.
FAU - Mayumi, Tadanori
AU  - Mayumi T
AD  - Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Osaka 
      University, Suita, Japan. mayumi@pharm.kobegakuin.ac.jp
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Vaccines)
SB  - IM
MH  - Animals
MH  - Cell- and Tissue-Based Therapy
MH  - Directed Molecular Evolution
MH  - *Drug Delivery Systems
MH  - Genetic Therapy
MH  - Humans
MH  - Nanotechnology
MH  - Proteomics
MH  - Vaccines
RF  - 131
EDAT- 2004/07/06 05:00
MHDA- 2004/08/28 05:00
CRDT- 2004/07/06 05:00
PHST- 2004/07/06 05:00 [pubmed]
PHST- 2004/08/28 05:00 [medline]
PHST- 2004/07/06 05:00 [entrez]
AID - 10.1248/yakushi.124.397 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2004 Jul;124(7):397-415. doi: 10.1248/yakushi.124.397.