PMID- 15235358
OWN - NLM
STAT- MEDLINE
DCOM- 20040826
LR  - 20151119
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 114
IP  - 7
DP  - 2004 Jul
TI  - A study of moderately differentiated neuroendocrine carcinomas of the larynx and 
      an examination of non-neoplastic larynx tissue for neuroendocrine cells.
PG  - 1264-70
AB  - OBJECTIVES/HYPOTHESIS: To determine the most appropriate terminology for 
      neuroendocrine carcinomas (NEC) of the larynx, successive clinicopathologic 
      studies are encouraged. The typical location and immunophenotype of laryngeal NEC 
      raise a question of whether any precursor cells exist. STUDY DESIGN: Six patients 
      with laryngeal NEC were analyzed. Another 20 laryngectomy specimens were examined 
      for the presence of non-neoplastic neuroendocrine cells. METHODS: Tumor 
      morphology and patient outcome were determined, and tumor tissue underwent 
      immunohistochemical examination to identify cytokeratin, neuroendocrine markers 
      (chromogranin, synaptophysin, CD56, calcitonin), S-100 protein, and p53 protein. 
      A neuroendocrine marker study was also performed on non-neoplastic regions of 
      another 20 laryngectomy specimens to identify any neuroendocrine cells. RESULTS: 
      Laryngeal NEC, all submucosal, exhibited various morphology with or without 
      histologic evidences of neuroendocrine differentiation. The tumors showed 
      frequent (67%) calcitonin expression, calcitonin secretion in one case, and 
      common (50%) p53 over-expression. Three patients died within 3 years. In the 
      non-neoplastic larynx specimens, Kulchitsky cell-like bipolar neuroendocrine 
      cells were identified in the basal and middle layer of the respiratory epithelium 
      of the ventricle and subglottis but none in the submucosal layer of the 
      supraglottic region. The neuroendocrine cells did not express calcitonin. 
      CONCLUSIONS: Moderately differentiated or large-cell NEC is a more favored term 
      than atypical carcinoid until more refined classifications for upper respiratory 
      tract NEC are agreed on. Despite the confirmed presence of neuroendocrine cells 
      in the respiratory epithelium of the larynx, the origin of laryngeal NEC remains 
      unknown. p53 mutation might be one of the major molecular steps in the 
      pathogenesis of laryngeal NEC.
FAU - Chung, Jin-Haeng
AU  - Chung JH
AD  - Department of Pathology, Korea Cancer Center Hospital, Seoul, South Korea.
FAU - Lee, Seung-Sook
AU  - Lee SS
FAU - Shim, Yoon-Sang
AU  - Shim YS
FAU - Kim, Sang-Yoon
AU  - Kim SY
FAU - Nam, Soon-Yuhl
AU  - Nam SY
FAU - Kim, Dong-Hoon
AU  - Kim DH
FAU - Cho, Kyung-Ja
AU  - Cho KJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Aged
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Neuroendocrine/*pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Laryngeal Neoplasms/*pathology
MH  - Larynx/*pathology
MH  - Male
MH  - Middle Aged
EDAT- 2004/07/06 05:00
MHDA- 2004/08/27 05:00
CRDT- 2004/07/06 05:00
PHST- 2004/07/06 05:00 [pubmed]
PHST- 2004/08/27 05:00 [medline]
PHST- 2004/07/06 05:00 [entrez]
AID - 00005537-200407000-00023 [pii]
AID - 10.1097/00005537-200407000-00023 [doi]
PST - ppublish
SO  - Laryngoscope. 2004 Jul;114(7):1264-70. doi: 10.1097/00005537-200407000-00023.