PMID- 15235611
OWN - NLM
STAT- MEDLINE
DCOM- 20050125
LR  - 20191210
IS  - 1087-0156 (Print)
IS  - 1087-0156 (Linking)
VI  - 22
IP  - 8
DP  - 2004 Aug
TI  - In silico simulation of biological network dynamics.
PG  - 1017-9
AB  - Realistic simulation of biological networks requires stochastic simulation 
      approaches because of the small numbers of molecules per cell. The high 
      computational cost of stochastic simulation on conventional microprocessor-based 
      computers arises from the intrinsic disparity between the sequential steps 
      executed by a microprocessor program and the highly parallel nature of 
      information flow within biochemical networks. This disparity is reduced with the 
      Field Programmable Gate Array (FPGA)-based approach presented here. The parallel 
      architecture of FPGAs, which can simulate the basic reaction steps of biological 
      networks, attains simulation rates at least an order of magnitude greater than 
      currently available microprocessors.
FAU - Salwinski, Lukasz
AU  - Salwinski L
AD  - UCLA-DOE Institute for Genomics and Proteomics, Howard Hughes Medical Institute, 
      Molecular Biology Institute, Los Angeles, CA 90095-1570, USA.
FAU - Eisenberg, David
AU  - Eisenberg D
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20040704
PL  - United States
TA  - Nat Biotechnol
JT  - Nature biotechnology
JID - 9604648
RN  - 0 (Multienzyme Complexes)
SB  - IM
CIN - Nat Biotechnol. 2004 Aug;22(8):964-5. PMID: 15286647
MH  - *Algorithms
MH  - Animals
MH  - *Cell Physiological Phenomena
MH  - *Computer Simulation
MH  - *Computing Methodologies
MH  - Feasibility Studies
MH  - Gene Expression Regulation/physiology
MH  - Humans
MH  - Kinetics
MH  - Metabolism/physiology
MH  - *Models, Biological
MH  - Models, Statistical
MH  - Multienzyme Complexes/metabolism
MH  - Signal Transduction/*physiology
MH  - *Stochastic Processes
EDAT- 2004/07/06 05:00
MHDA- 2005/01/26 09:00
CRDT- 2004/07/06 05:00
PHST- 2004/03/16 00:00 [received]
PHST- 2004/05/07 00:00 [accepted]
PHST- 2004/07/06 05:00 [pubmed]
PHST- 2005/01/26 09:00 [medline]
PHST- 2004/07/06 05:00 [entrez]
AID - nbt991 [pii]
AID - 10.1038/nbt991 [doi]
PST - ppublish
SO  - Nat Biotechnol. 2004 Aug;22(8):1017-9. doi: 10.1038/nbt991. Epub 2004 Jul 4.