PMID- 15235966
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20050207
LR  - 20181113
IS  - 0913-8668 (Print)
IS  - 0913-8668 (Linking)
VI  - 4
IP  - 4
DP  - 1990 Oct
TI  - The effects of nicardipine given after 10-minutes complete global cerebral 
      ischemia on neurologic recovery in dogs.
PG  - 337-42
AB  - The effect of nicardipine (NC) on neurologic recovery from ischemic insult after 
      10-minutes complete global cerebral ischemia was evaluated in dogs by examination 
      of neurologic recovery score (NRS: complete recovery = 100, death = 0). Ischemia 
      was achieved by occlusion of ascending aorta, and NC, 10 microg.kg(-1) in bolus 
      followed by infusion of 0.33 microg.kg(-1).min(-1) for 2 hours, was administered 
      immediately after re-establishment of circulation. The mortality at 7th day was 
      2/9 in the control Copyright and 1/9 in the NC group (ns). NRS on 2nd day was 
      52.3 +/- 6.8 in the C and 70.6 +/- 6.5 in the NC ( P < 0.05), but that on 7th day 
      did not differ between the two groups. The numbers of dogs recovered to over 80 
      in NRS on the 2nd day was 1/9 in the C and 5/9 in the NC ( P < 0.05), but that on 
      the 7th day increased to 3/9 in the C and remained at 5/9 in the NC (ns). These 
      results suggest that NC accelerates the early neurologic recovery from ischemic 
      damage, but influences little the final outcome.
FAU - Iwatsuki, N
AU  - Iwatsuki N
AD  - Department of Anesthesiology, Tohoku University School of Medicine, Sendai, 
      Japan.
FAU - Ono, K
AU  - Ono K
FAU - Takahashi, M
AU  - Takahashi M
FAU - Tajima, T
AU  - Tajima T
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - J Anesth
JT  - Journal of anesthesia
JID - 8905667
EDAT- 1990/10/01 00:00
MHDA- 1990/10/01 00:01
CRDT- 1990/10/01 00:00
PHST- 1989/11/15 00:00 [received]
PHST- 1990/06/12 00:00 [accepted]
PHST- 1990/10/01 00:00 [pubmed]
PHST- 1990/10/01 00:01 [medline]
PHST- 1990/10/01 00:00 [entrez]
AID - 10.1007/s0054000040337 [doi]
PST - ppublish
SO  - J Anesth. 1990 Oct;4(4):337-42. doi: 10.1007/s0054000040337.