PMID- 15236764
OWN - NLM
STAT- MEDLINE
DCOM- 20041115
LR  - 20131121
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 39
IP  - 7
DP  - 2004 Jul
TI  - Circulating adiponectin levels increase in rats on caloric restriction: the 
      potential for insulin sensitization.
PG  - 1049-59
AB  - Caloric restriction (CR) has a well-known insulin sensitizing effect in vivo. 
      Although this effect has been confirmed in rodents and primates for many years, 
      its precise molecular mechanisms remain unknown. Here we show a significant 
      increase in plasma adiponectin and a decrease in blood glucose, plasma 
      triglyceride and insulin levels in rats maintained on CR diet for 2, 10, 15, and 
      20 months. Long-term CR rats exhibited significantly higher insulin-stimulated 
      insulin receptor tyrosine phosphorylation and lower PTP-1B activity both in liver 
      and skeletal muscle than those observed in rats fed ad libitum (AL). In addition, 
      the triglyceride levels in these tissues were significantly lower in long-term CR 
      animals. Interestingly, concentrations of plasma adiponectin in long-term CR rats 
      were associated with increased expression of the transcription factor mRNAs for 
      the peroxisome proliferator-activated receptor (PPAR)alpha, gamma and delta, but 
      decreased expression for SREBP-1c, resulting in a concerted modulation in the 
      expression of key transcription target genes involved in fatty acid oxidation and 
      energy combustion in liver. Taken together, our findings suggest an important 
      role for adiponectin in the beneficial effects of long-term CR.
FAU - Zhu, Min
AU  - Zhu M
AD  - Laboratory of Experimental Gerontology, Gerontology Research Center, National 
      Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, 
      Baltimore, MD 21224, USA.
FAU - Miura, Junnosuke
AU  - Miura J
FAU - Lu, Lucy X
AU  - Lu LX
FAU - Bernier, Michel
AU  - Bernier M
FAU - DeCabo, Rafael
AU  - DeCabo R
FAU - Lane, Mark A
AU  - Lane MA
FAU - Roth, George S
AU  - Roth GS
FAU - Ingram, Donald K
AU  - Ingram DK
LA  - eng
PT  - Journal Article
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Adiponectin)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Proteins)
RN  - 0 (Triglycerides)
RN  - 42HK56048U (Tyrosine)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 1)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
RN  - EC 3.1.3.48 (Ptpn1 protein, rat)
SB  - IM
MH  - Adiponectin
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Weight
MH  - *Caloric Restriction
MH  - Gene Expression Regulation/physiology
MH  - Insulin/*blood
MH  - *Intercellular Signaling Peptides and Proteins
MH  - Liver/metabolism
MH  - Male
MH  - Muscle, Skeletal/metabolism
MH  - Pancreas/metabolism
MH  - Phosphorylation
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 1
MH  - Protein Tyrosine Phosphatases/metabolism
MH  - Proteins/*metabolism
MH  - Rats
MH  - Rats, Inbred F344
MH  - Signal Transduction/physiology
MH  - Triglycerides/blood
MH  - Tyrosine/metabolism
EDAT- 2004/07/09 05:00
MHDA- 2004/11/16 09:00
CRDT- 2004/07/09 05:00
PHST- 2004/01/07 00:00 [received]
PHST- 2004/03/03 00:00 [revised]
PHST- 2004/03/05 00:00 [accepted]
PHST- 2004/07/09 05:00 [pubmed]
PHST- 2004/11/16 09:00 [medline]
PHST- 2004/07/09 05:00 [entrez]
AID - S0531556504001287 [pii]
AID - 10.1016/j.exger.2004.03.024 [doi]
PST - ppublish
SO  - Exp Gerontol. 2004 Jul;39(7):1049-59. doi: 10.1016/j.exger.2004.03.024.