PMID- 15239092
OWN - NLM
STAT- MEDLINE
DCOM- 20040727
LR  - 20111117
IS  - 0270-9139 (Print)
IS  - 0270-9139 (Linking)
VI  - 40
IP  - 1
DP  - 2004 Jul
TI  - Distinct MHC class I and II alleles are associated with hepatitis C viral 
      clearance, originating from a single source.
PG  - 108-14
AB  - The role of cytotoxic T lymphocyte responses, restricted by human leukocyte 
      antigen (HLA) class I alleles, is recognized as highly significant in the 
      successful clearance of hepatitis C virus (HCV). The frequency of class I alleles 
      in females inoculated with HCV genotype 1b from a single source was examined for 
      an association with outcome. Class I typing was performed using polymerase chain 
      reaction sequence-specific primers in 227 female subjects: 141 had chronic 
      infection and 86 had viral clearance. Statistical analysis included chi(2) 
      testing and multiple logistic regression analysis. A*03, B*27, and Cw*01 occurred 
      more frequently in those with viral clearance (39.5%, 14%, and 9.3%, 
      respectively) compared with those with chronic infection (19.1%, 2.1%, and 1.4%, 
      respectively; P < or = .005). B*08 occurred more often in those with chronic 
      infection compared with viral clearance (39.7% vs. 19.8%; P =.002). In 
      combination with previously reported class II allele associations, over 75% that 
      successfully eliminate HCV carry either A*03, DRB1*0101, or *0401, compared with 
      only 37% of those with chronic infection (P <.0001). The haplotypes 
      A*03-B*07-DRB1*15-DQB1*0602 and A*02-B*27-Cw*01-DRB1*0101-DQB1*0501 are 
      associated with viral clearance (P =.004 and.01, respectively). By multiple 
      logistic regression analysis, the alleles A*03, B*27, DRB1*0101, *0401, and *15 
      are associated with viral clearance, and B*27 has the strongest association (odds 
      ratio [OR] 7.99). The haplotype A*01-B*08-Cw*07-DRB1*03011-DQB1*0201 is 
      associated with chronic infection (P =.002), being independent for DQB1*0201 (OR 
      0.27). In conclusion, certain class I alleles are associated with outcome in this 
      homogeneous cohort. More significantly, either HLA-A*03, -DRB1*0101, or -*0401 
      are carried by an overwhelming majority of those subjects who successfully clear 
      HCV.
FAU - McKiernan, Susan M
AU  - McKiernan SM
AD  - Hepatology Center, St. James's Hospital and Trinity College, Dublin, Ireland. 
      smckiernan@stjames.ie
FAU - Hagan, Richard
AU  - Hagan R
FAU - Curry, Michael
AU  - Curry M
FAU - McDonald, George S A
AU  - McDonald GS
FAU - Kelly, Alan
AU  - Kelly A
FAU - Nolan, Niamh
AU  - Nolan N
FAU - Walsh, Anne
AU  - Walsh A
FAU - Hegarty, John
AU  - Hegarty J
FAU - Lawlor, Emer
AU  - Lawlor E
FAU - Kelleher, Dermot
AU  - Kelleher D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A*03 antigen)
RN  - 0 (HLA-A3 Antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*01:01 antigen)
RN  - 0 (Rho(D) Immune Globulin)
SB  - IM
MH  - *Alleles
MH  - Cohort Studies
MH  - Drug Contamination
MH  - Female
MH  - *Genes, MHC Class I
MH  - *Genes, MHC Class II
MH  - HLA-A Antigens/genetics
MH  - HLA-A3 Antigen
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Hepacivirus
MH  - Hepatitis C, Chronic/etiology/*genetics/*virology
MH  - Humans
MH  - Middle Aged
MH  - Rho(D) Immune Globulin/therapeutic use
MH  - *Viral Load
EDAT- 2004/07/09 05:00
MHDA- 2004/07/28 05:00
CRDT- 2004/07/09 05:00
PHST- 2004/07/09 05:00 [pubmed]
PHST- 2004/07/28 05:00 [medline]
PHST- 2004/07/09 05:00 [entrez]
AID - 10.1002/hep.20261 [doi]
PST - ppublish
SO  - Hepatology. 2004 Jul;40(1):108-14. doi: 10.1002/hep.20261.