PMID- 15239396
OWN - NLM
STAT- MEDLINE
DCOM- 20040720
LR  - 20220409
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 79
IP  - 5
DP  - 2004 Jun
TI  - Extramedullary relapse confirmed by fluorescence in situ hybridization study of 
      an ear mass in acute promyelocytic leukemia.
PG  - 462-4
AB  - A 40-year-old man with acute promyelocytic leukemia (APL) achieved complete 
      remission after induction chemotherapy combined with all-trans-retinoic acid. A 
      mass developed in the left ear 24 months later. Relapse of APL was suspected at 
      morphologic examination of the biopsy specimen of the ear mass, but t(15;17) and 
      PML/RAR alpha rearrangement were not detected by chromosomal, fluorescence in 
      situ hybridization (FISH), or reverse transcription polymerase chain reaction 
      analysis of bone marrow samples. FISH performed on the ear mass revealed 
      t(15;17). To our knowledge, this case is the first reported case of 
      extramedullary relapse of APL confirmed by FISH study of a biopsy specimen of 
      extramedullary tissue.
FAU - Lee, Keun-Wook
AU  - Lee KW
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Yi, Jongyoun
AU  - Yi J
FAU - Yun, Tak
AU  - Yun T
FAU - Kim, Dae-Young
AU  - Kim DY
FAU - Lee, Dong Soon
AU  - Lee DS
FAU - Park, Sung Sup
AU  - Park SS
FAU - Cho, Han Ik
AU  - Cho HI
FAU - Yoon, Sung-Soo
AU  - Yoon SS
FAU - Park, Seonyang
AU  - Park S
FAU - Kim, Byoung Kook
AU  - Kim BK
FAU - Kim, Noe Kyeong
AU  - Kim NK
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Chromosome Aberrations
MH  - *Chromosomes, Human, Pair 15
MH  - Ear Neoplasms/*genetics/*pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Promyelocytic, Acute/drug therapy/*genetics/*pathology
MH  - Male
MH  - Neoplasm Recurrence, Local/*diagnosis/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2004/07/09 05:00
MHDA- 2004/07/21 05:00
CRDT- 2004/07/09 05:00
PHST- 2004/07/09 05:00 [pubmed]
PHST- 2004/07/21 05:00 [medline]
PHST- 2004/07/09 05:00 [entrez]
AID - 10.1532/ijh97.a10320 [doi]
PST - ppublish
SO  - Int J Hematol. 2004 Jun;79(5):462-4. doi: 10.1532/ijh97.a10320.