PMID- 15240159
OWN - NLM
STAT- MEDLINE
DCOM- 20040818
LR  - 20061115
IS  - 1521-6616 (Print)
IS  - 1521-6616 (Linking)
VI  - 112
IP  - 2
DP  - 2004 Aug
TI  - beta2-glycoprotein I, the playmaker of the antiphospholipid syndrome.
PG  - 161-8
AB  - From its discovery in the early 60s till the beginning of the 90s, there was not 
      much interest in plasma protein beta2-glycoprotein I (beta2-GPI). The finding 
      that beta2-GPI acts as an essential cofactor for the detection of 
      antiphospholipid antibodies (aPL) tremendously increased the interest in 
      beta2-GPI [Lancet 335 (1990) 1544; Lancet 336 (1990) 177; Proc. Natl. Acad. Sci. 
      U. S. A. 87 (1990) 4120]. It is now generally accepted that autoantibodies 
      directed towards beta2-GPI are not only a serological marker but that they are 
      involved in the pathology of the antiphospholipid syndrome (APS). In this review, 
      we will first discuss the biochemistry of the protein beta2-GPI and the influence 
      that the antibodies have on the function of beta2-GPI. Next, we will discuss the 
      problems that are faced when assays to detect the presence of the autoantibodies 
      are performed, emphasizing the urgent need for standardization of the 
      anti-beta2-GPI-ELISA. Finally, we will discuss our latest insights into beta2-GPI 
      and its role in the pathology of APS. Thereby, we will focus on the role of 
      dimerized beta2-GPI on platelet and endothelial cell function.
FAU - Bas de Laat, H
AU  - Bas de Laat H
AD  - Department of Haematology, Thrombosis and Haemostasis Laboratory, University 
      Medical Center Utrecht, The Netherlands.
FAU - Derksen, Ronald H W M
AU  - Derksen RH
FAU - de Groot, Philip G
AU  - de Groot PG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Antibodies, Antiphospholipid)
RN  - 0 (Glycoproteins)
RN  - 0 (beta 2-Glycoprotein I)
SB  - IM
MH  - Animals
MH  - Antibodies, Antiphospholipid/*analysis/chemistry/immunology
MH  - Antiphospholipid Syndrome/*immunology/physiopathology
MH  - Dimerization
MH  - Enzyme-Linked Immunosorbent Assay/standards
MH  - Glycoproteins/*chemistry/*immunology
MH  - Humans
MH  - beta 2-Glycoprotein I
RF  - 57
EDAT- 2004/07/09 05:00
MHDA- 2004/08/19 05:00
CRDT- 2004/07/09 05:00
PHST- 2004/02/13 00:00 [received]
PHST- 2004/02/27 00:00 [accepted]
PHST- 2004/07/09 05:00 [pubmed]
PHST- 2004/08/19 05:00 [medline]
PHST- 2004/07/09 05:00 [entrez]
AID - S1521661604000609 [pii]
AID - 10.1016/j.clim.2004.02.012 [doi]
PST - ppublish
SO  - Clin Immunol. 2004 Aug;112(2):161-8. doi: 10.1016/j.clim.2004.02.012.