PMID- 15240531
OWN - NLM
STAT- MEDLINE
DCOM- 20050131
LR  - 20061115
IS  - 1078-0432 (Print)
IS  - 1078-0432 (Linking)
VI  - 10
IP  - 13
DP  - 2004 Jul 1
TI  - Mouse mammary tumor-like virus is associated with p53 nuclear accumulation and 
      progesterone receptor positivity but not estrogen positivity in human female 
      breast cancer.
PG  - 4417-9
AB  - PURPOSE: The purpose is to compare the presence of proteins with known 
      associations with breast cancer-progesterone receptor (PgR), estrogen receptor, 
      and p53, with the prevalence of mouse mammary tumor virus (MMTV)-like DNA 
      sequences in human female breast cancers. EXPERIMENTAL DESIGN: A cohort of 128 
      Australian female breast cancers were screened for MMTV-like DNA sequences using 
      PCR. The presence of PgR, estrogen receptor, and nuclear accumulation of p53 
      protein was assessed in the same samples using immunohistochemical staining. 
      RESULTS: Nuclear accumulation of p53 was significantly more prevalent (P = 0.05) 
      in archival human breast cancers containing MMTV-like DNA sequences. The presence 
      of progesterone receptor was significantly higher in MMTV-positive than 
      MMTV-negative breast cancers (P = 0.01). No correlation between estrogen receptor 
      and MMTV-like DNA sequences was found. CONCLUSIONS: MMTV causes breast cancer in 
      mice, and hormones up-regulate expression of virus in mice mammary tissue. It is 
      unknown if this is the case in human breast cancers shown to contain DNA of 
      MMTV-like viruses. The positive association between MMTV-like DNA sequences and 
      PgR indicates hormones and MMTV may play a role in human breast cancer. Mutations 
      of the tumor suppressor gene p53 are common in human breast cancer and are 
      associated with higher grades of cancer. The association of MMTV-like DNA 
      sequences with higher grades of cancer, and the positive association between p53 
      and MMTV-like DNA sequences clearly warrant additional investigation.
FAU - Faedo, Margaret
AU  - Faedo M
AD  - Virology Division, Department of Microbiology, South Eastern Area Laboratory 
      Services, The Prince of Wales Hospital, Randwick, Australia. faedom@sesahs.nsw
FAU - Ford, Caroline E
AU  - Ford CE
FAU - Mehta, Reena
AU  - Mehta R
FAU - Blazek, Katrina
AU  - Blazek K
FAU - Rawlinson, William D
AU  - Rawlinson WD
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for 
      Cancer Research
JID - 9502500
RN  - 0 (DNA, Viral)
RN  - 0 (Estrogens)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 9007-49-2 (DNA)
SB  - IM
CIN - Clin Cancer Res. 2005 Jan 1;11(1):406; author reply 406. PMID: 15671572
MH  - Breast Neoplasms/*metabolism
MH  - Carcinoma, Ductal, Breast/metabolism
MH  - Cell Nucleus/*metabolism
MH  - DNA/chemistry
MH  - DNA, Viral/metabolism
MH  - Estrogens/*metabolism
MH  - Female
MH  - Genes, p53
MH  - Humans
MH  - Immunohistochemistry
MH  - Mammary Tumor Virus, Mouse/*metabolism
MH  - Mutation
MH  - Receptors, Estrogen/metabolism
MH  - Receptors, Progesterone/metabolism
MH  - Tumor Suppressor Protein p53/*biosynthesis/metabolism
EDAT- 2004/07/09 05:00
MHDA- 2005/02/03 09:00
CRDT- 2004/07/09 05:00
PHST- 2004/07/09 05:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/07/09 05:00 [entrez]
AID - 10/13/4417 [pii]
AID - 10.1158/1078-0432.CCR-03-0232 [doi]
PST - ppublish
SO  - Clin Cancer Res. 2004 Jul 1;10(13):4417-9. doi: 10.1158/1078-0432.CCR-03-0232.