PMID- 15240926
OWN - NLM
STAT- MEDLINE
DCOM- 20050106
LR  - 20190727
IS  - 0040-8727 (Print)
IS  - 0040-8727 (Linking)
VI  - 203
IP  - 3
DP  - 2004 Jul
TI  - Effects of desalted deep seawater on hematologic and blood chemical values in 
      mice.
PG  - 175-82
AB  - Various processed foods and beverages have been manufactured using deep seawater 
      (DSW), desalted DSW (dDSW), and concentrated DSW in Japan. To confirm the safety 
      of dDSW, we investigated hematologic and blood chemical effects of dDSW in mice. 
      The dDSW and desalted surface seawater (dSSW) were diluted to 6.7%, 10%, and 20% 
      with purified water. BALB/c mice were housed for 12 weeks, and administered the 
      diluted dDSW, dSSW, or purified water as a control during the period. The results 
      for dDSW were compared with those for dSSW and purified water. None of the groups 
      of mice showed any clear abnormal growth or behavior; neither did any show signs 
      of illness nor a single case of death during the 12 weeks study. We found no 
      significant differences between the dDSW and control groups in terms of red blood 
      cell count, hemoglobin, hematocrit, white blood cell count, and neutrophil 
      counts, whereas white blood cell and lymphocyte counts were significantly higher 
      in the 10% dSSW group at the end of 4 and 12 weeks than those in the control 
      group. A significantly higher triglyceride level was detected only in the 6.7% 
      dSSW group. Our results show no evidence of acute or subacute effects of diluted 
      dDSW. Effects of diluted dDSW on hematologic and blood chemical values in mice 
      are thought to be similar to those of purified water. This finding suggests that 
      dDSW is as safe as purified water for drinking water.
FAU - Tsuchiya, Yasuo
AU  - Tsuchiya Y
AD  - Department of Community Preventive Medicine, Niigata University Graduate School 
      of Medical and Dental Sciences, Niigata.troof@med.niigata-u.ac.jp
FAU - Watanabe, Atsuo
AU  - Watanabe A
FAU - Fujisawa, Nobuyoshi
AU  - Fujisawa N
FAU - Kaneko, Takushi
AU  - Kaneko T
FAU - Ishizu, Teiji
AU  - Ishizu T
FAU - Fujimoto, Takanori
AU  - Fujimoto T
FAU - Nakamura, Kazutoshi
AU  - Nakamura K
FAU - Yamamoto, Masaharu
AU  - Yamamoto M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (Triglycerides)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Animals
MH  - Blood Chemical Analysis
MH  - Female
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Neutrophils/metabolism
MH  - *Seawater
MH  - Triglycerides/metabolism
MH  - Water/*metabolism
MH  - Water Purification
MH  - Water Supply
EDAT- 2004/07/09 05:00
MHDA- 2005/01/07 09:00
CRDT- 2004/07/09 05:00
PHST- 2004/07/09 05:00 [pubmed]
PHST- 2005/01/07 09:00 [medline]
PHST- 2004/07/09 05:00 [entrez]
AID - 10.1620/tjem.203.175 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2004 Jul;203(3):175-82. doi: 10.1620/tjem.203.175.