PMID- 15241467
OWN - NLM
STAT- MEDLINE
DCOM- 20050210
LR  - 20061115
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 5
IP  - 6
DP  - 2004 Sep
TI  - Death receptor 3 (DR3) gene duplication in a chromosome region 1p36.3: gene 
      duplication is more prevalent in rheumatoid arthritis.
PG  - 439-43
AB  - The death receptor 3 (DR3) gene is a member of the apoptosis-inducing Fas gene 
      family. In the current study, fluorescence in situ hybridization (FISH) and 
      Fiber-FISH revealed the existence of a second DR3 gene approximately 200 kb 
      upstream of the original DR3 gene. The existence of the duplicated DR3 gene was 
      confirmed by sequencing the corresponding human artificial chromosome clones as 
      well as with quantitative PCR that measured the ratio of the DR3 gene mutation 
      (Rm), intrinsic to rheumatoid arthritis (RA) patients, by simultaneous 
      amplification of the normal and mutated DR3 sequences. The DR3 gene duplication 
      measured by FISH was found to be more frequent in patients with RA as compared to 
      healthy individuals. We therefore surmise that the human DR3 gene can be 
      duplicated and that this gene duplication is more prevalent in patients with RA.
FAU - Osawa, K
AU  - Osawa K
AD  - Department of Rheumatology, Kobe University FHS School of Medicine, Kobe, Japan.
FAU - Takami, N
AU  - Takami N
FAU - Shiozawa, K
AU  - Shiozawa K
FAU - Hashiramoto, A
AU  - Hashiramoto A
FAU - Shiozawa, S
AU  - Shiozawa S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Member 25)
RN  - 0 (TNFRSF25 protein, human)
SB  - IM
MH  - Arthritis, Rheumatoid/*genetics
MH  - Base Sequence
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - *Gene Duplication
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Molecular Sequence Data
MH  - Mutation/genetics
MH  - Polymerase Chain Reaction
MH  - Prevalence
MH  - Receptors, Tumor Necrosis Factor/*genetics
MH  - Receptors, Tumor Necrosis Factor, Member 25
MH  - Sequence Homology, Nucleic Acid
EDAT- 2004/07/09 05:00
MHDA- 2005/02/11 09:00
CRDT- 2004/07/09 05:00
PHST- 2004/07/09 05:00 [pubmed]
PHST- 2005/02/11 09:00 [medline]
PHST- 2004/07/09 05:00 [entrez]
AID - 6364097 [pii]
AID - 10.1038/sj.gene.6364097 [doi]
PST - ppublish
SO  - Genes Immun. 2004 Sep;5(6):439-43. doi: 10.1038/sj.gene.6364097.