PMID- 15241486
OWN - NLM
STAT- MEDLINE
DCOM- 20050511
LR  - 20061115
IS  - 1018-4813 (Print)
IS  - 1018-4813 (Linking)
VI  - 12
IP  - 11
DP  - 2004 Nov
TI  - Familial correlations and inter-relationships of four asthma-associated 
      quantitative phenotypes in 320 French EGEA families ascertained through asthmatic 
      probands.
PG  - 955-63
AB  - Asthma is a complex disease, associated with biological and physiological 
      phenotypes including immunoglobulin E (IgE) levels, sum of positive skin prick 
      tests to allergens (SPTQ), eosinophil counts (EOS) and percent predicted forced 
      expiratory volume in 1 s (%FEV1). We investigated the patterns of familial 
      correlations and the inter-relationships of these four quantitative phenotypes, 
      using the general class D regressive model, in 320 French EGEA nuclear families 
      ascertained through 204 offspring (set A) and 116 parents (set B). Familial 
      correlations of IgE and SPTQ were consistent with a model including no spouse 
      correlation and equal parent-offspring and sib-sib correlations (rhoPO = rhoSS = 
      0.25 for IgE and 0.15 for SPTQ), this model being compatible with an additive 
      polygenic model in the whole sample and the two family subsets A and B. Different 
      patterns of familial correlations of EOS and %FEV1 were observed in these two 
      sets. In set A, the best fitting model included no spouse correlation and 
      equality of parent-offspring and sib-sib correlations (rhoPO = rhoSS = 0.14 for 
      EOS and 0.23 for %FEV1). In set B, EOS had only a significant rhoSS of 0.28, 
      while %FEV1 had significant rhoMO of 0.28 and rhoSS of 0.16. Analysis of shared 
      familial determinants between these phenotypes indicated an overlap of at most 
      30% in rhoFO for IgE and SPTQ and in both rhoFO and rhoMO for IgE and EOS, while 
      determinants of %FEV1 and atopy-related phenotypes appear distinct. These results 
      may have implications for further linkage and association studies with genetic 
      markers.
FAU - Bouzigon, Emmanuelle
AU  - Bouzigon E
AD  - INSERM-Universite d'Evry EMI0006, Evry, France. bouzigon@evry.inserm.fr
FAU - Chaudru, Valerie
AU  - Chaudru V
FAU - Carpentier, Anne-Sophie
AU  - Carpentier AS
FAU - Dizier, Marie-Helene
AU  - Dizier MH
FAU - Oryszczyn, Marie-Pierre
AU  - Oryszczyn MP
FAU - Maccario, Jean
AU  - Maccario J
FAU - Kauffmann, Francine
AU  - Kauffmann F
FAU - Demenais, Florence
AU  - Demenais F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Asthma/*genetics
MH  - Birth Order
MH  - Child
MH  - Female
MH  - France/epidemiology
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Likelihood Functions
MH  - Male
MH  - Middle Aged
MH  - Nuclear Family
MH  - Phenotype
MH  - Regression Analysis
MH  - Sex Factors
MH  - Smoking
EDAT- 2004/07/09 05:00
MHDA- 2005/05/12 09:00
CRDT- 2004/07/09 05:00
PHST- 2004/07/09 05:00 [pubmed]
PHST- 2005/05/12 09:00 [medline]
PHST- 2004/07/09 05:00 [entrez]
AID - 5201241 [pii]
AID - 10.1038/sj.ejhg.5201241 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2004 Nov;12(11):955-63. doi: 10.1038/sj.ejhg.5201241.