PMID- 15241825
OWN - NLM
STAT- MEDLINE
DCOM- 20040726
LR  - 20220331
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 101
IP  - 2
DP  - 2004 Jul 15
TI  - Adult Wilms' tumor: A monoinstitutional experience and a review of the 
      literature.
PG  - 289-93
AB  - BACKGROUND: The authors reviewed their institutional experience regarding adult 
      patients with Wilms' tumor (WT) to assess their clinical characteristics and 
      compliance with respect to children's treatment guidelines. METHODS: A total of 
      17 adult patients (median age at the time of diagnosis of 17.5 years; range, 
      16-29 years) were referred to the study institute between 1983 and 2001 and were 
      followed for a median of 131 months. The treatment modality was planned according 
      to the two consecutive Italian protocols for WT that were active during the 
      referral years. The patients were staged according to the National Wilms Tumor 
      Study-4 (NWTS) staging system as follows: eight patients had Stage II disease, 
      four patients had Stage III disease, and five patients had Stage IV disease. 
      RESULTS: All the patients but one underwent nephrectomy, with three incomplete 
      surgeries performed. Two patients with Stage II disease were treated elsewhere 
      with nephrectomy only and they were admitted to the study institution at the time 
      of disease recurrence. Anaplasia was found to be present in only one patient with 
      Stage IV disease. The authors noted 9 cases of disease recurrence or progression 
      occurring during treatment and 6 of these 9 patients died of their disease, with 
      an overall survival rate of 62.4% at 5 years. CONCLUSIONS: Compared with 
      children, adults with WT are reported to have a worse prognosis. In the current 
      study, the authors found that poor compliance with specific therapeutic 
      guidelines may contribute to this poorer outcome. Because of the rarity of this 
      disease, adults with WT are at a risk of either undertreatment or incorrect 
      treatment.
CI  - Copyright 2004 American Cancer Society.
FAU - Terenziani, Monica
AU  - Terenziani M
AD  - Unita di Oncologia Pediatrica, Istituto Nazionale per lo Studio e la Cura dei 
      Tumori, Milan, Italy. monica.terenziani@istitutotumori.mi.it
FAU - Spreafico, Filippo
AU  - Spreafico F
FAU - Collini, Paola
AU  - Collini P
FAU - Piva, Luigi
AU  - Piva L
FAU - Perotti, Daniela
AU  - Perotti D
FAU - Podda, Marta
AU  - Podda M
FAU - Gandola, Lorenza
AU  - Gandola L
FAU - Massimino, Maura
AU  - Massimino M
FAU - Cereda, Stefano
AU  - Cereda S
FAU - Cefalo, Graziella
AU  - Cefalo G
FAU - Luksch, Roberto
AU  - Luksch R
FAU - Casanova, Michela
AU  - Casanova M
FAU - Ferrari, Andrea
AU  - Ferrari A
FAU - Polastri, Daniela
AU  - Polastri D
FAU - Valagussa, Pinuccia
AU  - Valagussa P
FAU - Fossati-Bellani, Franca
AU  - Fossati-Bellani F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Kidney Neoplasms/diagnosis/mortality/therapy
MH  - Male
MH  - Nephrectomy
MH  - Survival Rate
MH  - Wilms Tumor/*diagnosis/mortality/therapy
RF  - 16
EDAT- 2004/07/09 05:00
MHDA- 2004/07/28 05:00
CRDT- 2004/07/09 05:00
PHST- 2004/07/09 05:00 [pubmed]
PHST- 2004/07/28 05:00 [medline]
PHST- 2004/07/09 05:00 [entrez]
AID - 10.1002/cncr.20387 [doi]
PST - ppublish
SO  - Cancer. 2004 Jul 15;101(2):289-93. doi: 10.1002/cncr.20387.