PMID- 15242461
OWN - NLM
STAT- MEDLINE
DCOM- 20041007
LR  - 20131121
IS  - 0266-8254 (Print)
IS  - 0266-8254 (Linking)
VI  - 39
IP  - 2
DP  - 2004
TI  - Virucidal activity of the new disinfectant monopercitric acid.
PG  - 194-8
AB  - AIMS: The virucidal efficacy of monopercitric acid (MPCA) was evaluated against 
      the enveloped vaccinia virus as well as the nonenveloped adenovirus type 2 and 
      poliovirus type 1. The results were compared with that obtained with peracetic 
      acid (PAA). METHODS AND RESULTS: In the virucidal suspension test without and 
      with protein burden, all viruses were inactivated by 0.5% MPCA within 0.5 min or 
      by 0.1% MPCA within 5 min as measured by a >10(4)-fold reduction in virus titres. 
      For MPCA, there was a better virucidal efficacy than for PAA which inactivated 
      all viruses included in the test within 15-30 min at a concentration of 0.2%. 
      SIGNIFICANCE AND IMPACT OF THE STUDY: The high virucidal activity, short exposure 
      times, and nontoxic by-products seem to make MPCA suitable as disinfectant for 
      medical use and should warrant further investigation.
FAU - Wutzler, P
AU  - Wutzler P
AD  - Institute of Virology and Antiviral Therapy, Friedrich-Schiller University, Jena, 
      Germany.
FAU - Sauerbrei, A
AU  - Sauerbrei A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Lett Appl Microbiol
JT  - Letters in applied microbiology
JID - 8510094
RN  - 0 (Antiviral Agents)
RN  - 0 (Citrates)
RN  - 0 (Disinfectants)
RN  - 0 (monopercitric acid)
RN  - I6KPI2E1HD (Peracetic Acid)
SB  - IM
MH  - Adenoviridae/drug effects
MH  - Antiviral Agents/*pharmacology
MH  - Citrates/chemistry/*pharmacology
MH  - Disinfectants/chemistry/*pharmacology
MH  - Humans
MH  - Peracetic Acid/pharmacology
MH  - Poliovirus/drug effects
MH  - Vaccinia virus/drug effects
MH  - Viruses/chemistry/drug effects
EDAT- 2004/07/10 05:00
MHDA- 2004/10/08 09:00
CRDT- 2004/07/10 05:00
PHST- 2004/07/10 05:00 [pubmed]
PHST- 2004/10/08 09:00 [medline]
PHST- 2004/07/10 05:00 [entrez]
AID - LAM1561 [pii]
AID - 10.1111/j.1472-765X.2004.01561.x [doi]
PST - ppublish
SO  - Lett Appl Microbiol. 2004;39(2):194-8. doi: 10.1111/j.1472-765X.2004.01561.x.