PMID- 15243926
OWN - NLM
STAT- MEDLINE
DCOM- 20040824
LR  - 20221207
IS  - 0022-1899 (Print)
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Linking)
VI  - 190
IP  - 3
DP  - 2004 Aug 1
TI  - Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) 
      genotypes with susceptibility and resistance to the development of severe acute 
      respiratory syndrome.
PG  - 515-8
AB  - Severe acute respiratory syndrome (SARS) is a public health concern worldwide. By 
      studying the human leukocyte antigen (HLA) types A, B, DR, and DQ alleles in 90 
      Chinese patients with serologically confirmed SARS infections, we identified a 
      strong association between HLA-B*0703 (OR, 4.08; 95% CI, 2.03-8.18; P=.00072 
      [Bonferroni-corrected P value, P(c) <.0022]) and -DRB1*0301 (OR, 0.06; 95%, 
      0.01-0.47; P=.00008 [after Bonferroni correction, P<.0042]) and the development 
      of SARS. Moreover, the frequency of B*0703 and B60 coinheritance (9.6%; 95% CI, 
      4.6%-19.0%) in our SARS group was significantly higher (P=3x10(-9)) than that 
      expected in the general population (0.4%). These genetic data will critically 
      affect both the study of the pathogenesis of SARS and the design of vaccination 
      programs.
FAU - Ng, Margaret H L
AU  - Ng MH
AD  - Department of Anatomical and Cellular Pathology, The Chinese University of Hong 
      Kong, Prince of Wales Hospital, Hong Kong SAR, China. margaretng@cuhk.edu.hk
FAU - Lau, Kin-Mang
AU  - Lau KM
FAU - Li, Libby
AU  - Li L
FAU - Cheng, Suk-Hang
AU  - Cheng SH
FAU - Chan, Wing Y
AU  - Chan WY
FAU - Hui, Pak K
AU  - Hui PK
FAU - Zee, Benny
AU  - Zee B
FAU - Leung, Chi-Bon
AU  - Leung CB
FAU - Sung, Joseph J Y
AU  - Sung JJ
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040707
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Disease Susceptibility
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genetic Testing
MH  - Genotype
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Severe acute respiratory syndrome-related coronavirus/*pathogenicity
MH  - Severe Acute Respiratory Syndrome/*genetics/*immunology/physiopathology
MH  - Severity of Illness Index
PMC - PMC7109646
EDAT- 2004/07/10 05:00
MHDA- 2004/08/25 05:00
PMCR- 2004/08/01
CRDT- 2004/07/10 05:00
PHST- 2003/10/31 00:00 [received]
PHST- 2004/01/09 00:00 [accepted]
PHST- 2004/07/10 05:00 [pubmed]
PHST- 2004/08/25 05:00 [medline]
PHST- 2004/07/10 05:00 [entrez]
PHST- 2004/08/01 00:00 [pmc-release]
AID - JID32010 [pii]
AID - 10.1086/421523 [doi]
PST - ppublish
SO  - J Infect Dis. 2004 Aug 1;190(3):515-8. doi: 10.1086/421523. Epub 2004 Jul 7.