PMID- 15245373
OWN - NLM
STAT- MEDLINE
DCOM- 20050128
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 64
IP  - 2
DP  - 2004 Aug
TI  - Human leukocyte antigen-A, -B and -C alleles and human leukocyte antigen 
      haplotypes in Turkey: relationship to other populations.
PG  - 180-7
AB  - In this study, we present, for the first time, human leukocyte antigen (HLA) 
      class I allele and haplotype frequencies at the DNA level in a sample of 142 
      donors from Turkey. HLA typing was performed by medium-to-high resolution 
      polymerase chain reaction sequence-specific oligonucleotide probes method. The 
      most frequent HLA alleles at class I locus were A*0201(0.257), -B*35(0.204) and 
      -Cw*04(0.173). A*0201-B*35-Cw*04(0.056) was the most common three-locus 
      haplotype. Allele and haplotype frequency comparisons and neighbour-joining 
      dendrograms, constructed using DA genetic distances and correspondence analysis 
      using HLA-A, -B and -C, and -DRB1 allele frequencies, revealed similarities with 
      other Mediterranean and European populations, but not with Mongol populations. 
      These results agree with previous studies and confirm that the present day 
      Turkish population is genetically more similar to its geographic neighbours than 
      its historical neighbours in central Asia. The comprehensive HLA data on the 
      Turkish population at the DNA level including up to six-locus putative haplotypes 
      generated in this study will be useful for further studies.
FAU - Uyar, F A
AU  - Uyar FA
AD  - Istanbul University, Istanbul Medical Faculty, Department of Physiology, 
      Istanbul, Turkey.
FAU - Dorak, M T
AU  - Dorak MT
FAU - Saruhan-Direskeneli, G
AU  - Saruhan-Direskeneli G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - *Alleles
MH  - Asian People
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - HLA-DR Antigens/genetics
MH  - *Haplotypes
MH  - Humans
MH  - Mediterranean Region
MH  - Turkey
MH  - White People
EDAT- 2004/07/13 05:00
MHDA- 2005/01/29 09:00
CRDT- 2004/07/13 05:00
PHST- 2004/07/13 05:00 [pubmed]
PHST- 2005/01/29 09:00 [medline]
PHST- 2004/07/13 05:00 [entrez]
AID - TAN258 [pii]
AID - 10.1111/j.1399-0039.2004.00258.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 Aug;64(2):180-7. doi: 10.1111/j.1399-0039.2004.00258.x.