PMID- 15245376
OWN - NLM
STAT- MEDLINE
DCOM- 20050128
LR  - 20081121
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 64
IP  - 2
DP  - 2004 Aug
TI  - Lack of association between the -2518G/A polymorphism of the MCP-1 gene and 
      ischaemic heart disease: a family-based investigation.
PG  - 199-203
AB  - Using two recently described family-based tests of association, the possible role 
      of the functional -2518G/A polymorphism in the promoter region of the monocyte 
      chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart 
      disease (IHD) was investigated in a well-defined Irish population. One thousand 
      and twelve individuals from 386 families with at least one member prematurely 
      affected with IHD were genotyped for the MCP-1 -2518G/A polymorphism. Using the 
      combined transmission disequilibrium test and the pedigree disequilibrium test, 
      no association between the MCP-1 -2518G/A polymorphism and IHD was found. Our 
      data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is 
      not strongly associated with IHD.
FAU - McGlinchey, P G
AU  - McGlinchey PG
AD  - Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, UK.
FAU - Spence, M S
AU  - Spence MS
FAU - Patterson, C C
AU  - Patterson CC
FAU - Allen, A R
AU  - Allen AR
FAU - Murphy, G
AU  - Murphy G
FAU - Belton, C
AU  - Belton C
FAU - McKeown, P P
AU  - McKeown PP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Chemokine CCL2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Ireland
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*genetics
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic/genetics/physiology
EDAT- 2004/07/13 05:00
MHDA- 2005/01/29 09:00
CRDT- 2004/07/13 05:00
PHST- 2004/07/13 05:00 [pubmed]
PHST- 2005/01/29 09:00 [medline]
PHST- 2004/07/13 05:00 [entrez]
AID - TAN281 [pii]
AID - 10.1111/j.0001-2815.2004.00281.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 Aug;64(2):199-203. doi: 10.1111/j.0001-2815.2004.00281.x.