PMID- 15245377
OWN - NLM
STAT- MEDLINE
DCOM- 20050128
LR  - 20101118
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 64
IP  - 2
DP  - 2004 Aug
TI  - Polymorphism of HLA class I genes in the Brazilian population from the 
      Northeastern State of Pernambuco corroborates anthropological evidence of its 
      origin.
PG  - 204-9
AB  - The allelic distribution of human leukocyte antigen (HLA) class I genes (HLA-A, 
      HLA-B, and HLA-Cw) of the population from the State of Pernambuco in Northeastern 
      Brazil was studied in a sample of 101 healthy unrelated individuals. Low to 
      medium resolution HLA class I typing was performed using polymerase chain 
      reaction-amplified DNA hybridized to sequence specific primers (PCR-SSPs). Twenty 
      allele groups were detected for HLA-A, 28 for HLA-B, and 14 for HLA-Cw. The most 
      frequent alleles were HLA-A*02(0.2871), HLA-B*15(0.1238), and HLA-Cw*04(0.2277), 
      and the most frequent genotypes were A*02/A*02(0.0990), B*15/B*15(0.0594), and 
      Cw*04/Cw*04 and Cw*07/Cw*07, both with a frequency of 0.0792. The observed 
      heterozygosity for the studied loci was 79.21% for HLA-A, 87.13% for HLA-B, and 
      77.23% for HLA-Cw. The most frequent haplotype was A*02-Cw*04-B*35(0.0485), which 
      is also present in Western European, Amerindian, and Brazilian Mulatto 
      populations, but absent in African populations. Taken together, these data 
      corroborate the historic anthropological evidences of the origin of the 
      Northeastern Brazilian population from Pernambuco.
FAU - Nigam, P
AU  - Nigam P
AD  - Laboratory of Human Molecular Genetics, Federal University of Pernambuco, 
      Recife-PE, Brazil.
FAU - Dellalibera, E
AU  - Dellalibera E
FAU - Mauricio-da-Silva, L
AU  - Mauricio-da-Silva L
FAU - Donadi, E A
AU  - Donadi EA
FAU - Silva, R S
AU  - Silva RS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
SB  - IM
MH  - Biological Evolution
MH  - Brazil
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - Humans
MH  - *Polymorphism, Genetic
EDAT- 2004/07/13 05:00
MHDA- 2005/01/29 09:00
CRDT- 2004/07/13 05:00
PHST- 2004/07/13 05:00 [pubmed]
PHST- 2005/01/29 09:00 [medline]
PHST- 2004/07/13 05:00 [entrez]
AID - TAN264 [pii]
AID - 10.1111/j.1399-0039.2004.00264.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 Aug;64(2):204-9. doi: 10.1111/j.1399-0039.2004.00264.x.