PMID- 15245744
OWN - NLM
STAT- MEDLINE
DCOM- 20050322
LR  - 20061115
IS  - 0952-7915 (Print)
IS  - 0952-7915 (Linking)
VI  - 16
IP  - 4
DP  - 2004 Aug
TI  - Pathogens use carbohydrates to escape immunity induced by dendritic cells.
PG  - 488-93
AB  - Dendritic cells (DCs) play a central role in balancing immune responses between 
      tolerance induction and immune activation. Under steady state conditions DCs 
      continuously sample antigens, leading to tolerance, whereas inflammatory 
      conditions activate DCs, inducing immune activation. DCs express C-type lectin 
      receptors (CLRs) for antigen capture and presentation, whereas Toll-like 
      receptors (TLRs) are involved in pathogen recognition and DC activation. Recent 
      data demonstrate that communication between TLRs and CLRs can affect the 
      direction of immune responses. Several pathogens specifically target CLRs to 
      subvert this communication to escape immune surveillance, either by inducing 
      tolerance or skewing the protective immune responses.
FAU - van Kooyk, Yvette
AU  - van Kooyk Y
AD  - Department of Molecular Cell Biology and Immunology, Vrije Universiteit Medical 
      Center Amsterdam, van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands. 
      Y.vanKooyk@vumc.nl
FAU - Engering, Anneke
AU  - Engering A
FAU - Lekkerkerker, Annemarie N
AU  - Lekkerkerker AN
FAU - Ludwig, Irene S
AU  - Ludwig IS
FAU - Geijtenbeek, Teunis B H
AU  - Geijtenbeek TB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Carbohydrates)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Bacteria/immunology/pathogenicity
MH  - Carbohydrates/*immunology
MH  - Communicable Diseases/*immunology/pathology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - *Immune Tolerance
MH  - Immunity
MH  - Lectins, C-Type/*immunology
MH  - Membrane Glycoproteins/*immunology
MH  - Receptors, Cell Surface/*immunology
MH  - Schistosoma/immunology/pathogenicity
MH  - Toll-Like Receptors
MH  - Viruses/immunology/pathogenicity
RF  - 50
EDAT- 2004/07/13 05:00
MHDA- 2005/03/23 09:00
CRDT- 2004/07/13 05:00
PHST- 2004/07/13 05:00 [pubmed]
PHST- 2005/03/23 09:00 [medline]
PHST- 2004/07/13 05:00 [entrez]
AID - S0952791504000792 [pii]
AID - 10.1016/j.coi.2004.05.010 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2004 Aug;16(4):488-93. doi: 10.1016/j.coi.2004.05.010.