PMID- 15247039
OWN - NLM
STAT- MEDLINE
DCOM- 20040820
LR  - 20131121
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1019
DP  - 2004 Jun
TI  - Short-term caloric restriction and sites of oxygen radical generation in kidney 
      and skeletal muscle mitochondria.
PG  - 333-42
AB  - Mitochondrial free radical generation is believed to be one of the principal 
      factors determining aging rate, and complexes I and III have been described as 
      the main sources of reactive oxygen species (ROS) within mitochondria in heart, 
      brain, and liver. Moreover, complex I ROS generation of heart and liver 
      mitochondria seems especially linked to aging rate both in comparative studies 
      between animals with different longevities and in caloric restriction models. 
      Caloric restriction (CR) is a well-documented manipulation that extends mean and 
      maximum longevity. One of the factors that appears to be involved in such life 
      span extension is the reduction in mitochondrial free radical generation at 
      complex I. We have performed two parallel investigations, one studying the effect 
      of short-term CR on oxygen radical generation in kidney and skeletal muscle 
      (gastrocnemius) mitochondria and a second one regarding location of mitochondrial 
      ROS-generating sites in these same tissues. In the former study, no effect of 
      short-term caloric restriction was observed in mitochondrial free radical 
      generation in either kidney or skeletal muscle. The latter study ruled out 
      complex II as a principal source of free radicals in kidney and in skeletal 
      muscle mitochondria, and, similar to previous investigations in heart and liver 
      organelles, the main free radical generators were located at complexes I and III 
      within the electron transport system.
FAU - Gredilla, Ricardo
AU  - Gredilla R
AD  - Department of Animal Biology-II (Animal Physiology), Faculty of Biology, 
      Complutense University, 28040 Madrid, Spain.
FAU - Phaneuf, Sharon
AU  - Phaneuf S
FAU - Selman, Colin
AU  - Selman C
FAU - Kendaiah, Suma
AU  - Kendaiah S
FAU - Leeuwenburgh, Christiaan
AU  - Leeuwenburgh C
FAU - Barja, Gustavo
AU  - Barja G
LA  - eng
GR  - AG 17994/AG/NIA NIH HHS/United States
GR  - AG 21042/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Free Radicals)
RN  - 0 (Reactive Oxygen Species)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Aging
MH  - Animals
MH  - *Caloric Restriction
MH  - Electron Transport
MH  - Free Radicals
MH  - Hydrogen Peroxide/pharmacology
MH  - Kidney/*metabolism
MH  - Longevity
MH  - Male
MH  - Mitochondria/*pathology
MH  - Muscle, Skeletal/*metabolism
MH  - Oxygen/*metabolism
MH  - Oxygen Consumption
MH  - Rats
MH  - Rats, Inbred F344
MH  - Reactive Oxygen Species
EDAT- 2004/07/13 05:00
MHDA- 2004/08/21 05:00
CRDT- 2004/07/13 05:00
PHST- 2004/07/13 05:00 [pubmed]
PHST- 2004/08/21 05:00 [medline]
PHST- 2004/07/13 05:00 [entrez]
AID - 1019/1/333 [pii]
AID - 10.1196/annals.1297.057 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2004 Jun;1019:333-42. doi: 10.1196/annals.1297.057.