PMID- 15247062
OWN - NLM
STAT- MEDLINE
DCOM- 20040820
LR  - 20081121
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1019
DP  - 2004 Jun
TI  - Long-lived alpha MUPA transgenic mice exhibit increased mitochondrion-mediated 
      apoptotic capacity.
PG  - 439-42
AB  - Caloric restriction (CR) is currently the only therapeutic intervention known to 
      attenuate aging in mammals, but the mechanisms underlying this phenomenon are 
      still poorly understood. To study this issue, the transgenic model of alpha MUPA 
      mice, which previously were reported to spontaneously eat less and live longer 
      compared with their wild-type (WT) control mice, were used. Currently, two 
      transgenic lines that eat less are available, thus implicating the transgenic 
      enzyme, that is, the urokinase-type plasminogen activator (uPA), in causing the 
      reduced appetite. Recently, several changes in the alpha MUPA liver were noted, 
      at the mitochondrial and cellular level, which consistently pointed to an 
      enhanced capacity to induce apoptosis. In addition, alpha MUPA mice showed a 
      reduced level of serum IGF-1 and a reduced incidence of spontaneously occurring 
      or carcinogen-induced tumors in several tissues. Overall, the alpha MUPA model 
      suggests that long-lasting, moderately increased apoptotic capacity, possibly 
      linked in part to modulation of serum IGF-1 and mitochondrial functions, could 
      play a role in the attenuation of aging in calorically restricted mice.
FAU - Tirosh, Oren
AU  - Tirosh O
AD  - Institute of Biochemistry, Food Science and Nutrition, Hebrew University of 
      Jerusalem, Rehovot 76100, Israel.
FAU - Schwartz, Betty
AU  - Schwartz B
FAU - Zusman, Igor
AU  - Zusman I
FAU - Kossoy, George
AU  - Kossoy G
FAU - Yahav, Shlomo
AU  - Yahav S
FAU - Miskin, Ruth
AU  - Miskin R
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 3.4.21.73 (Urokinase-Type Plasminogen Activator)
SB  - IM
MH  - Aging
MH  - Animals
MH  - *Apoptosis
MH  - Appetite
MH  - Caloric Restriction
MH  - Insulin-Like Growth Factor I/metabolism
MH  - *Longevity
MH  - Mice
MH  - *Mice, Transgenic
MH  - Mitochondria/metabolism/*pathology
MH  - Urokinase-Type Plasminogen Activator/metabolism
RF  - 10
EDAT- 2004/07/13 05:00
MHDA- 2004/08/21 05:00
CRDT- 2004/07/13 05:00
PHST- 2004/07/13 05:00 [pubmed]
PHST- 2004/08/21 05:00 [medline]
PHST- 2004/07/13 05:00 [entrez]
AID - 1019/1/439 [pii]
AID - 10.1196/annals.1297.080 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2004 Jun;1019:439-42. doi: 10.1196/annals.1297.080.