PMID- 15249468
OWN - NLM
STAT- MEDLINE
DCOM- 20040810
LR  - 20201208
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 126
IP  - 1
DP  - 2004 Jul
TI  - Transfusion-related acute lung injury: a review.
PG  - 249-58
AB  - Transfusion-related acute lung injury (TRALI) is an underreported complication of 
      transfusion therapy, and it is the third most common cause of 
      transfusion-associated death. TRALI is defined as noncardiogenic pulmonary edema 
      temporally related to transfusion therapy. The diagnosis of TRALI relies on 
      excluding other diagnoses such as sepsis, volume overload, and cardiogenic 
      pulmonary edema. Supportive diagnostic evidence includes identifying neutrophil 
      or human leukocyte antigen (HLA) antibodies in the donor or recipient plasma. All 
      plasma-containing blood products have been implicated in TRALI, with the majority 
      of cases linked to whole blood, packed RBCs, platelets, and fresh-frozen plasma. 
      The pathogenesis of TRALI may be explained by a "two-hit" hypothesis, with the 
      first "hit" being a predisposing inflammatory condition commonly present in the 
      operating room or ICU. The second hit may involve the passive transfer of 
      neutrophil or HLA antibodies from the donor or the transfusion of biologically 
      active lipids from older, cellular blood products. Treatment is supportive, with 
      a prognosis substantially better than most causes of clinical acute lung injury.
FAU - Looney, Mark R
AU  - Looney MR
AD  - Division of Pulmonary and Critical Care Medicine, Department of Medicine, 
      Cardiovascular Research Institute, University of California, San Francisco, 
      94143-0130, USA. mlooney@itsa.ucsf.edu
FAU - Gropper, Michael A
AU  - Gropper MA
FAU - Matthay, Michael A
AU  - Matthay MA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
SB  - IM
CIN - Chest. 2005 Jul;128(1):470-1. PMID: 16002980
MH  - Adult
MH  - Animals
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Prognosis
MH  - *Respiratory Distress Syndrome/diagnosis/etiology/physiopathology
MH  - *Transfusion Reaction
RF  - 68
EDAT- 2004/07/14 05:00
MHDA- 2004/08/11 05:00
CRDT- 2004/07/14 05:00
PHST- 2004/07/14 05:00 [pubmed]
PHST- 2004/08/11 05:00 [medline]
PHST- 2004/07/14 05:00 [entrez]
AID - S0012-3692(15)32920-2 [pii]
AID - 10.1378/chest.126.1.249 [doi]
PST - ppublish
SO  - Chest. 2004 Jul;126(1):249-58. doi: 10.1378/chest.126.1.249.