PMID- 15249502
OWN - NLM
STAT- MEDLINE
DCOM- 20060407
LR  - 20220316
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 110
IP  - 10
DP  - 2004 Sep 7
TI  - CD34+ and endothelial progenitor cells in patients with various degrees of 
      congestive heart failure.
PG  - 1209-12
AB  - BACKGROUND: Peripheral blood CD34(+) cells and circulating endothelial progenitor 
      cells (EPCs) increase in myocardial infarction and vascular injuries as a 
      reflection of endothelial damage. Despite the occurrence of endothelial 
      dysfunction in heart failure (HF), no data are available on EPC mobilization in 
      this setting. We investigated the pattern of CD34(+) cells and EPC mobilization 
      during HF and their correlation with the severity and origin of the disease. 
      METHODS AND RESULTS: Peripheral blood CD34(+) cells (n=91) and EPCs (n=41), 
      assessed both as CD34(+) cells coexpressing AC133 and vascular endothelial growth 
      factor (VEGF) receptor-2 and as endothelial colony-forming units, were studied in 
      HF patients (mean age 67+/-11 years) and 45 gender- and age-matched controls. 
      Tumor necrosis factor-alpha (TNF-alpha) and its receptors (sTNFR-1 and sTNFR-2), 
      VEGF, stromal derived factor-1 (SDF-1), granulocyte-colony stimulating factor 
      (G-CSF), and B-type natriuretic peptide were also measured. CD34(+) cells, EPCs, 
      TNF-alpha and receptors, VEGF, SDF-1, and B-type natriuretic peptide were 
      increased in HF. CD34(+) cells and EPCs were inversely related to functional 
      class and to TNF-alpha, being decreased in New York Heart Association class IV 
      compared with class I and II and controls. No role was found for the origin of 
      the disease. CONCLUSIONS: CD34(+) cells and EPC mobilization occurs in HF and 
      shows a biphasic response, with elevation and depression in the early and 
      advanced phases, respectively. This could be related to the myelosuppressive role 
      of TNF-alpha.
FAU - Valgimigli, Marco
AU  - Valgimigli M
AD  - University of Ferrara and Cardiovascular Research Center, Salvatore Maugeri 
      Foundation, IRCCS, Gussago, Italy. vlgmrc@unife.it
FAU - Rigolin, Gian Matteo
AU  - Rigolin GM
FAU - Fucili, Alessandro
AU  - Fucili A
FAU - Porta, Matteo Della
AU  - Porta MD
FAU - Soukhomovskaia, Olga
AU  - Soukhomovskaia O
FAU - Malagutti, Patrizia
AU  - Malagutti P
FAU - Bugli, Anna Maria
AU  - Bugli AM
FAU - Bragotti, Letizia Zenone
AU  - Bragotti LZ
FAU - Francolini, Gloria
AU  - Francolini G
FAU - Mauro, Endri
AU  - Mauro E
FAU - Castoldi, Gianluigi
AU  - Castoldi G
FAU - Ferrari, Roberto
AU  - Ferrari R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040712
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Antigens, CD34)
RN  - 0 (Biomarkers)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, CD34/*analysis
MH  - Biomarkers
MH  - Chemokine CXCL12
MH  - Chemokines, CXC/blood
MH  - Colony-Forming Units Assay
MH  - Endothelium, Vascular/pathology
MH  - Female
MH  - Granulocyte Colony-Stimulating Factor/blood
MH  - Heart Failure/*blood
MH  - *Hematopoietic Stem Cells/chemistry
MH  - Humans
MH  - Male
MH  - *Mesenchymal Stem Cells/chemistry
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Receptors, Tumor Necrosis Factor, Type I/blood
MH  - Receptors, Tumor Necrosis Factor, Type II/blood
MH  - Tumor Necrosis Factor-alpha/analysis
MH  - Vascular Endothelial Growth Factor A/blood
MH  - Vascular Endothelial Growth Factor Receptor-2/analysis
EDAT- 2004/07/14 05:00
MHDA- 2006/04/08 09:00
CRDT- 2004/07/14 05:00
PHST- 2004/07/14 05:00 [pubmed]
PHST- 2006/04/08 09:00 [medline]
PHST- 2004/07/14 05:00 [entrez]
AID - 01.CIR.0000136813.89036.21 [pii]
AID - 10.1161/01.CIR.0000136813.89036.21 [doi]
PST - ppublish
SO  - Circulation. 2004 Sep 7;110(10):1209-12. doi: 10.1161/01.CIR.0000136813.89036.21. 
      Epub 2004 Jul 12.