PMID- 15249690
OWN - NLM
STAT- MEDLINE
DCOM- 20040826
LR  - 20231105
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 101
IP  - 29
DP  - 2004 Jul 20
TI  - Trim5alpha protein restricts both HIV-1 and murine leukemia virus.
PG  - 10786-91
AB  - Replication of HIV-1 and N-tropic murine leukemia virus (N-MLV) is restricted in 
      a number of different primate cells. In some cell lines, cross-saturation 
      experiments suggest that the two viruses are interacting with the same 
      restriction factor. Recently, Trim5alpha protein from rhesus monkey was found to 
      restrict HIV-1. We have confirmed this result and have shown that Trim5alpha from 
      two African green monkey cell lines, Vero and CV-1, also restricts HIV-1. In 
      addition, we show that human, rhesus, and African green monkey Trim5alpha can 
      restrict N-MLV. By using a panel of MLV capsid mutants, subtle differences in the 
      anti-MLV activity were identified among the different primate Trim5alpha cDNAs. 
      Trim1 isolated from humans and green monkeys was also found to restrict N-MLV. We 
      hypothesize that the Trim family of proteins plays a widespread role in innate 
      immunity to viral infection.
FAU - Yap, Melvyn W
AU  - Yap MW
AD  - Division of Virology, National Institute for Medical Research, The Ridgeway, Mill 
      Hill, London NW7 1AA, United Kingdom.
FAU - Nisole, Sebastien
AU  - Nisole S
FAU - Lynch, Clare
AU  - Lynch C
FAU - Stoye, Jonathan P
AU  - Stoye JP
LA  - eng
SI  - GENBANK/AY625000
SI  - GENBANK/AY625001
SI  - GENBANK/AY625002
SI  - GENBANK/AY625003
SI  - GENBANK/AY625004
SI  - GENBANK/AY625005
SI  - GENBANK/AY625006
SI  - GENBANK/AY625007
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040712
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Antiviral Restriction Factors)
RN  - 0 (Capsid Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (TRAT1 protein, human)
RN  - 0 (Tripartite Motif Proteins)
RN  - EC 2.3.2.27 (TRIM5 protein, human)
RN  - EC 2.3.2.27 (TRIM5(alpha) protein, rhesus monkey)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
SB  - IM
CIN - Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10496-7. PMID: 15252204
MH  - *Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antiviral Restriction Factors
MH  - Capsid Proteins/genetics/metabolism
MH  - Carrier Proteins/genetics/*metabolism
MH  - Cell Line
MH  - Chlorocebus aethiops
MH  - HIV-1/*physiology
MH  - Humans
MH  - Leukemia Virus, Murine/*physiology
MH  - Macaca mulatta
MH  - Membrane Proteins/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Proteins/chemistry/genetics/*metabolism
MH  - RNA, Small Interfering/genetics/metabolism
MH  - Sequence Alignment
MH  - Tripartite Motif Proteins
MH  - Ubiquitin-Protein Ligases
MH  - *Virus Replication
PMC - PMC490012
EDAT- 2004/07/14 05:00
MHDA- 2004/08/27 05:00
PMCR- 2005/01/20
CRDT- 2004/07/14 05:00
PHST- 2004/07/14 05:00 [pubmed]
PHST- 2004/08/27 05:00 [medline]
PHST- 2004/07/14 05:00 [entrez]
PHST- 2005/01/20 00:00 [pmc-release]
AID - 0402876101 [pii]
AID - 10110786 [pii]
AID - 10.1073/pnas.0402876101 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10786-91. doi: 
      10.1073/pnas.0402876101. Epub 2004 Jul 12.