PMID- 15250050
OWN - NLM
STAT- MEDLINE
DCOM- 20040817
LR  - 20051116
IS  - 0513-5796 (Print)
IS  - 0513-5796 (Linking)
VI  - 45 Suppl
DP  - 2004 Jun 30
TI  - Strategies to improve dendritic cell-based immunotherapy against cancer.
PG  - 48-52
AB  - Dendritic cells (DCs) play a pivotal role in T cell-mediated immunity and have 
      been shown to induce strong antitumor immune responses in vitro and in vivo. 
      Various approaches utilizing different vaccine cell formats, cell numbers, 
      vaccination schedule, site of vaccination and maturation stages of DCs were 
      investigated worldwide. While clinical trials have demonstrated the safety of 
      such strategies, the clinical outcome was less than expected in most cases. This 
      is due to in part host immunodeficiency imposed by tumors and immunoediting of 
      tumor cells. To overcome these obstacles, new approaches to improve DC-mediated 
      immunotherapeutic strategies are under investigation. First, functional 
      enhancement of monocyte-derived DCs can be generated with using flt3-ligand (FL). 
      Second, diverse antigenic determinants from heat shock-treated tumor cells may 
      improve the immunogenicity of DC-based vaccines. Third, inclusion of ex vivo 
      expanded NK/NKT cells in DC-based vaccines could be beneficial since the 
      bidirectional interaction of these two cell types are known to enhance NK cell 
      effector function and to induce DC maturation. Application of these approaches 
      may induce a broadened antitumor immune response and thereby promote the 
      elimination of tumor antigen-negative variant clones that had escaped 
      immunosurveillance or undergone immunoediting. We are currently examining the 
      feasibility of these immunotherapeutic approaches using a murine pancreatic 
      cancer model system.
FAU - Song, Si Young
AU  - Song SY
AD  - Brain Korea 21 Project for Medical Science, Yonsei University College of 
      Medicine, Seoul, Korea.
FAU - Kim, Han-Soo
AU  - Kim HS
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunotherapy/*methods/*standards
MH  - Neoplasms/*therapy
RF  - 33
EDAT- 2004/07/14 05:00
MHDA- 2004/08/18 05:00
CRDT- 2004/07/14 05:00
PHST- 2004/07/14 05:00 [pubmed]
PHST- 2004/08/18 05:00 [medline]
PHST- 2004/07/14 05:00 [entrez]
AID - 200406s048 [pii]
AID - 10.3349/ymj.2004.45.Suppl.48 [doi]
PST - ppublish
SO  - Yonsei Med J. 2004 Jun 30;45 Suppl:48-52. doi: 10.3349/ymj.2004.45.Suppl.48.