PMID- 15251256
OWN - NLM
STAT- MEDLINE
DCOM- 20050126
LR  - 20131121
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 78
IP  - 3
DP  - 2004 Jul
TI  - Testosterone's metabolism in the hippocampus may mediate its anti-anxiety effects 
      in male rats.
PG  - 473-81
AB  - Androgens may mediate anxiety behaviors; however, these effects and mechanisms of 
      androgens are not well understood. The following experiments investigated whether 
      testosterone (T)'s effects on anxiety behavior are mediated by its 
      5alpha-reduced, nonaromatizable metabolite dihydrotestosterone (DHT) and/or its 
      3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) reduced metabolite 
      3alpha-androstanediol (3alpha-diol). In Experiment 1, gonadally-intact adult male 
      rats and gonadectomized (GDX), DHT-replaced rats had similar low levels of 
      anxiety behavior in the open field and elevated plus maze and fear behavior in 
      the defensive freezing task compared with GDX control rats. In Experiment 2, 
      intact or DHT-replaced rats that received blank inserts to the hippocampus 
      demonstrated less anxiety behavior than did rats administered an implant of 
      indomethacin, a 3alpha-HSD inhibitor, to the dorsal hippocampus. These data 
      indicate that T's 5alpha-reduced metabolite, DHT, can reduce anxiety behavior and 
      that blocking metabolism to 3alpha-diol in the hippocampus can attenuate these 
      effects.
FAU - Frye, Cheryl A
AU  - Frye CA
AD  - Department of Psychology, State University of New York at Albany, 1400 Washington 
      Avenue, Albany, NY 12222, USA. cafrye@cnsunix.albany.edu
FAU - Edinger, Kassandra L
AU  - Edinger KL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Anti-Anxiety Agents)
RN  - 08J2K08A3Y (Dihydrotestosterone)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 1.1.1.50 (3-alpha-Hydroxysteroid Dehydrogenase (B-Specific))
SB  - IM
MH  - 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)/*physiology
MH  - Animals
MH  - Anti-Anxiety Agents/*pharmacology
MH  - Dihydrotestosterone/*metabolism
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Maze Learning/drug effects
MH  - Rats
MH  - Rats, Long-Evans
MH  - Testosterone/metabolism/*pharmacology
EDAT- 2004/07/15 05:00
MHDA- 2005/01/27 09:00
CRDT- 2004/07/15 05:00
PHST- 2004/03/18 00:00 [received]
PHST- 2004/03/31 00:00 [revised]
PHST- 2004/04/13 00:00 [accepted]
PHST- 2004/07/15 05:00 [pubmed]
PHST- 2005/01/27 09:00 [medline]
PHST- 2004/07/15 05:00 [entrez]
AID - S009130570400142X [pii]
AID - 10.1016/j.pbb.2004.04.019 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2004 Jul;78(3):473-81. doi: 10.1016/j.pbb.2004.04.019.