PMID- 15251257
OWN - NLM
STAT- MEDLINE
DCOM- 20050126
LR  - 20131121
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 78
IP  - 3
DP  - 2004 Jul
TI  - Androgens in the hippocampus can alter, and be altered by, ictal activity.
PG  - 483-93
AB  - Steroid hormones, such as androgens, can modulate seizure processes. This review 
      summarizes prior research and presents new data that support the role of 
      androgens in modulating seizure processes. Testosterone, the primary endogenous 
      androgen, has antiseizure effects in people and in animal models of epilepsy. 
      Furthermore, testosterone's antiseizure effects may involve actions of its 
      5alpha-reduced metabolite and neuroactive steroid, 
      5alpha-androstane-3alpha,17beta-diol (3alpha-diol). The hippocampus is a target 
      for androgen action and is involved in many types of seizure disorder. Data 
      suggest that actions of androgens in the hippocampus may be important for 
      androgens' antiseizure effects. Interestingly, there may also be a reciprocal 
      relationship between androgens and seizures. Ictal activity can alter the gonadal 
      responsiveness of people with epilepsy and in animal models of seizure disorder. 
      Thus, this paper will review data in support of androgens' antiseizure effects. 
      Further understanding of androgens' role in seizure processes is important for 
      potential therapeutic effects.
FAU - Rhodes, Madeline E
AU  - Rhodes ME
AD  - Department of Psychology, The University at Albany-SUNY, Social Science 220, 1400 
      Washington Avenue, Albany, NY 12222, USA.
FAU - Frye, Cheryl A
AU  - Frye CA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Androgens)
RN  - WM5Z385K7T (Pentylenetetrazole)
SB  - IM
MH  - Androgens/*physiology
MH  - Animals
MH  - Disease Models, Animal
MH  - Epilepsy/physiopathology
MH  - Female
MH  - Hippocampus/*physiology
MH  - Humans
MH  - Male
MH  - Pentylenetetrazole
MH  - Reproduction
MH  - Seizures/*prevention & control
RF  - 82
EDAT- 2004/07/15 05:00
MHDA- 2005/01/27 09:00
CRDT- 2004/07/15 05:00
PHST- 2004/02/02 00:00 [received]
PHST- 2004/03/09 00:00 [revised]
PHST- 2004/04/13 00:00 [accepted]
PHST- 2004/07/15 05:00 [pubmed]
PHST- 2005/01/27 09:00 [medline]
PHST- 2004/07/15 05:00 [entrez]
AID - S0091305704001431 [pii]
AID - 10.1016/j.pbb.2004.04.020 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2004 Jul;78(3):483-93. doi: 10.1016/j.pbb.2004.04.020.